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The impact of non-photic stimuli on ...

Buxton, Orfeu Marcello.

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The impact of non-photic stimuli on human circadian rhythms: Exercise, darkness, sleep, and triazolam.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The impact of non-photic stimuli on human circadian rhythms: Exercise, darkness, sleep, and triazolam./
作者:	Buxton, Orfeu Marcello.
面頁冊數:	195 p.
附註:	Source: Dissertation Abstracts International, Volume: 61-06, Section: B, page: 2918.
Contained By:	Dissertation Abstracts International61-06B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9974259
ISBN:	0599797657

The impact of non-photic stimuli on human circadian rhythms: Exercise, darkness, sleep, and triazolam.
Buxton, Orfeu Marcello.

The impact of non-photic stimuli on human circadian rhythms: Exercise, darkness, sleep, and triazolam. - 195 p.

Source: Dissertation Abstracts International, Volume: 61-06, Section: B, page: 2918.

Thesis (Ph.D.)--Northwestern University, 2000.

The nonphotic inputs to the human circadian pacemaker were characterized by examining the phase-shifting effects of exercise and dark/sleep on hormonal markers of circadian phase in a "constant routine" protocol, and by determining the efficacy of triazolam administration to facilitate adaptation of hormonal and EEG-derived markers of circadian rhythmicity and sleep-wake homeostasis in a jet lag simulation.

ISBN: 0599797657Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The impact of non-photic stimuli on human circadian rhythms: Exercise, darkness, sleep, and triazolam.
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245 1 4 $a The impact of non-photic stimuli on human circadian rhythms: Exercise, darkness, sleep, and triazolam.
300 $a 195 p.
500 $a Source: Dissertation Abstracts International, Volume: 61-06, Section: B, page: 2918.
500 $a Adviser: Fred W. Turek.
502 $a Thesis (Ph.D.)--Northwestern University, 2000.
520 $a The nonphotic inputs to the human circadian pacemaker were characterized by examining the phase-shifting effects of exercise and dark/sleep on hormonal markers of circadian phase in a "constant routine" protocol, and by determining the efficacy of triazolam administration to facilitate adaptation of hormonal and EEG-derived markers of circadian rhythmicity and sleep-wake homeostasis in a jet lag simulation.
520 $a Experiment 1. 3 hour, moderate-intensity, nocturnal exercise sessions resulted in significant phase delays of melatonin and thyrotropin secretion onset 1 hour greater than control. 1 hour, high-intensity, nocturnal exercise sessions phase-delayed thyrotropin onsets, but a trend for phase delays of melatonin onsets to be greater than control failed to reach significance. Increased physical activity or arousal during the habitual rest period alters circadian phase.
520 $a Experiment 2. In response to 1 hour, high-intensity, daytime exercise sessions, circadian phase was shifted only by evening exercise, which acutely increased melatonin secretion and significantly advanced melatonin onsets. However, melatonin advances were reduced the following evening and may not represent steady-state phase shifts of the circadian system. A minimum duration or repetition of exercise may be necessary for reliable phase-shifting.
520 $a Experiment 3. 6 hour daytime naps (dark/sleep) in the morning resulted in phase delays whereas evening dark/sleep resulted in phase advances relative to controls who remained awake in dim light. Afternoon naps did not change phase.
520 $a Experiment 4. In a double-blind study of adaptation to an 8 hour delay shift of sleep-wake and light-dark cycles, triazolam was given three hours before the first shifted sleep/dark period, and at bedtime on days 2--5 post-shift. In addition to acutely promoting sleep at a shifted time, triazolam facilitated the adaptation of circadian rhythmicity (cortisol onset and REM distribution) and sleep-wake homeostasis (growth hormone secretion and sleep patterns) on the first and third days post-shift.
520 $a Modulations of circadian phase by nocturnal or evening exercise, daytime dark/sleep, and triazolam suggest that the phase-resetting and entrainment strategies used by night workers and those experiencing jet lag should consider not only the timing and intensity of light, but also the timing of exercise, darkness, and sleep.
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773 0 $t Dissertation Abstracts International $g 61-06B.
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