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Neural substrates of circadian rhyth...

Kaneko, Maki.

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Neural substrates of circadian rhythms in developing and adult Drosophila.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Neural substrates of circadian rhythms in developing and adult Drosophila./
作者:	Kaneko, Maki.
面頁冊數:	567 p.
附註:	Source: Dissertation Abstracts International, Volume: 61-01, Section: B, page: 0121.
Contained By:	Dissertation Abstracts International61-01B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9959637
ISBN:	0599631406

Neural substrates of circadian rhythms in developing and adult Drosophila.
Kaneko, Maki.

Neural substrates of circadian rhythms in developing and adult Drosophila. - 567 p.

Source: Dissertation Abstracts International, Volume: 61-01, Section: B, page: 0121.

Thesis (Ph.D.)--Brandeis University, 2000.

In Drosophila several genes have been identified, which are involved in the pacemaker of the circadian rhythm. Temporal expression studies of these genes revealed the feedback loop responsible for cycling products of clock genes as a core mechanism of intracellular circadian clocks. In contrast, spatial expression patterns of clock genes revealed cellular clocks responsible for specific rhythmic outputs.

ISBN: 0599631406Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Neural substrates of circadian rhythms in developing and adult Drosophila.
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500 $a Source: Dissertation Abstracts International, Volume: 61-01, Section: B, page: 0121.
500 $a Adviser: Jeffrey C. Hall.
502 $a Thesis (Ph.D.)--Brandeis University, 2000.
520 $a In Drosophila several genes have been identified, which are involved in the pacemaker of the circadian rhythm. Temporal expression studies of these genes revealed the feedback loop responsible for cycling products of clock genes as a core mechanism of intracellular circadian clocks. In contrast, spatial expression patterns of clock genes revealed cellular clocks responsible for specific rhythmic outputs.
520 $a I studied spatial expression patterns of clock genes period (per) and timeless (tim) in Drosophila during development as well as in adults with a special emphasis on the brain, which is a main pacemaking tissue responsible for behavioral rhythms. These patterns were reveled by antibodies against PER and TIM as well as by reporter genes driven by promoters of these clock genes. Then I performed behavioral experiments in order to assign specific roles of clock cells for the generation of rhythmic behavior.
520 $a I first found that per and tim are cyclically expressed in a few clusters of brains in larvae, including the Lateral Neurons (LNs) that give rise to adult pacemaker cells responsible for behavioral rhythms. Then I showed that per is involved in the phenomena of larval "time-memory" in which the larval pacemaker is entrained by a light stimulus, and such a pacemaker can control rhythmic outputs later in adulthood. The pacemaker responsible for time-memory seems to be the LNs, which show persistent rhythmic expression of per throughout the metamorphosis.
520 $a Two reporter genes, per-promoter- and tim-promoter- gal4 revealed aspects of clock cells that have not been discovered by other methods such as anti-PER and anti-TIM stainings as well as PER-beta-galactosidase (betaGAL) fusion protein expression. This includes neuronal processes from clock neurons that were revealed by driving marker proteins such as betaGAL, TAU, and green fluorescent protein. per- and tim-gal4 could be also used for behavioral studies by expressing proteins other than markers in clock cells: tetanus toxin light chain was used to block synaptic transmission in clock neurons, and PER was expressed to disrupt the feedback loop of the pacemaker. By these behavioral studies, I obtained evidence implying that neurons other than the LNs are involved in generation of adult activity rhythms.
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