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Behavior genetics of Drosophila pept...

Renn, Susan Christine Portia.

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Behavior genetics of Drosophila peptidergic systems.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Behavior genetics of Drosophila peptidergic systems./
Author:	Renn, Susan Christine Portia.
Description:	259 p.
Notes:	Source: Dissertation Abstracts International, Volume: 60-09, Section: B, page: 4449.
Contained By:	Dissertation Abstracts International60-09B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9947477
ISBN:	0599496894

Behavior genetics of Drosophila peptidergic systems.
Renn, Susan Christine Portia.

Behavior genetics of Drosophila peptidergic systems. - 259 p.

Source: Dissertation Abstracts International, Volume: 60-09, Section: B, page: 4449.

Thesis (Ph.D.)--Washington University, 1999.

The field of behavioral genetics strives to identify genes which influence an organism's behavior. Due to the complex relationship between a gene and a behavioral event it is logical study model organisms that are amenable to genetic manipulation. The classical and modern genetic techniques available for Drosophila offer several advantages which have been implemented in this thesis.

ISBN: 0599496894Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Behavior genetics of Drosophila peptidergic systems.
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100 1 $a Renn, Susan Christine Portia. $3 1907181
245 1 0 $a Behavior genetics of Drosophila peptidergic systems.
300 $a 259 p.
500 $a Source: Dissertation Abstracts International, Volume: 60-09, Section: B, page: 4449.
500 $a Chairperson: Paul Taghert.
502 $a Thesis (Ph.D.)--Washington University, 1999.
520 $a The field of behavioral genetics strives to identify genes which influence an organism's behavior. Due to the complex relationship between a gene and a behavioral event it is logical study model organisms that are amenable to genetic manipulation. The classical and modern genetic techniques available for Drosophila offer several advantages which have been implemented in this thesis.
520 $a The first study of this thesis employs the modern genetic technique of enhancer trap lines to analyze a neuro-anatomical structure, the ellipsoid body of the central complex, that is involved in the coordination of locomotor behavior. In order to describe the architecture of the central complex, I study fifteen enhancer-trap lines that label various ellipsoid body neuron types. I interpret the cellular morphology according to previous Golgi studies. This work adds a genetic, and therefore potentially functional, component to the description of this structure. Hypotheses concerning the central complex development are presented based upon enhancer trap analysis in wild type and mutant backgrounds.
520 $a The second study in this thesis arises from a classical genetic approach to identify a behavioral mutant. I have identified a specific mutant for the PDF neuropeptide, the neuropeptide expressed in the Drosophila pacemaker neurons. Through analysis of this mutant and PDF mutants which contain a rescue construct, I demonstrate that PDF is necessary for normal circadian behavior. The behavioral phenotype of the PDF mutant includes (i) strong rhythmicity with altered phasing under light/dark cycling conditions, and (ii) gradual degradation of rhythmic activity in &sim;80% of the animals under constant dark conditions. The complex behavioral phenotype suggests that PDF may play a role in both input and output to the circadian clock.
520 $a The third study in this thesis presents the cloning, characterization and expression pattern of Drosophila tripeptidyl peptidase II an enzyme homologous to a mammalian neuropeptidase that has been implicated in the regulation of feeding behavior. Neuropeptidase activity presents a possible mechanism by which neuropeptide activity might be regulated. This work initiates a genetic approach in Drosophila to study the role of neuropeptidase activity in the regulation of behavior.
590 $a School code: 0252.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Genetics. $3 1017730
690 $a 0317
690 $a 0369
710 2 0 $a Washington University. $3 1250147
773 0 $t Dissertation Abstracts International $g 60-09B.
790 1 0 $a Taghert, Paul, $e advisor
790 $a 0252
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9947477