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Investigation of the mechanism of ac...

Bard, Joel.

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Investigation of the mechanism of activation of inward rectifier potassium channels by muscarinic acetylcholine receptors.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigation of the mechanism of activation of inward rectifier potassium channels by muscarinic acetylcholine receptors./
Author:	Bard, Joel.
Description:	88 p.
Notes:	Source: Dissertation Abstracts International, Volume: 60-06, Section: B, page: 2537.
Contained By:	Dissertation Abstracts International60-06B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9935731
ISBN:	0599368179

Investigation of the mechanism of activation of inward rectifier potassium channels by muscarinic acetylcholine receptors.
Bard, Joel.

Investigation of the mechanism of activation of inward rectifier potassium channels by muscarinic acetylcholine receptors. - 88 p.

Source: Dissertation Abstracts International, Volume: 60-06, Section: B, page: 2537.

Thesis (Ph.D.)--Harvard University, 1999.

Activation of the inward rectifier potassium current I KACh is a primary means of regulation of the excitability of neurons and cardiac pacemaker cells. The biochemical events involved in this activation have been well studied. Activation of G protein coupled receptors leads to the production of free G protein bg subunits which bind to and activate the channels which mediate I KACh. The mechanism by which G protein binding activates these channels is less clear. As a step towards understanding this mechanism, I investigated the effect of receptor activation on single G protein sensitive channels. I found that activation of these channels increases the mean duration of bursts of channel openings. This result is consistent with a simple model of the transitions of the channel between the closed and bursting states.

ISBN: 0599368179Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Investigation of the mechanism of activation of inward rectifier potassium channels by muscarinic acetylcholine receptors.
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005 20060829133342.5
008 130610s1999 eng d
020 $a 0599368179
035 $a (UnM)AAI9935731
035 $a AAI9935731
040 $a UnM $c UnM
100 1 $a Bard, Joel. $3 1907177
245 1 0 $a Investigation of the mechanism of activation of inward rectifier potassium channels by muscarinic acetylcholine receptors.
300 $a 88 p.
500 $a Source: Dissertation Abstracts International, Volume: 60-06, Section: B, page: 2537.
500 $a Adviser: Ernest G. Peralta.
502 $a Thesis (Ph.D.)--Harvard University, 1999.
520 $a Activation of the inward rectifier potassium current I KACh is a primary means of regulation of the excitability of neurons and cardiac pacemaker cells. The biochemical events involved in this activation have been well studied. Activation of G protein coupled receptors leads to the production of free G protein bg subunits which bind to and activate the channels which mediate I KACh. The mechanism by which G protein binding activates these channels is less clear. As a step towards understanding this mechanism, I investigated the effect of receptor activation on single G protein sensitive channels. I found that activation of these channels increases the mean duration of bursts of channel openings. This result is consistent with a simple model of the transitions of the channel between the closed and bursting states.
590 $a School code: 0084.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biophysics, General. $3 1019105
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0317
690 $a 0786
690 $a 0433
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 60-06B.
790 1 0 $a Peralta, Ernest G., $e advisor
790 $a 0084
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9935731