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Mechanisms subserving the direct eff...

Miller, Ann M.

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Mechanisms subserving the direct effects of light on sleep in rats.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Mechanisms subserving the direct effects of light on sleep in rats./
作者:	Miller, Ann M.
面頁冊數:	229 p.
附註:	Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3272.
Contained By:	Dissertation Abstracts International59-07B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9835199
ISBN:	0591954044

Mechanisms subserving the direct effects of light on sleep in rats.
Miller, Ann M.

Mechanisms subserving the direct effects of light on sleep in rats. - 229 p.

Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3272.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 1998.

Patterns of sleep and wakefulness in humans and other mammals are regulated by the light-dark cycle. Light has the ability to entrain the circadian (or 24 hour) pacemaker, and it is also able to influence behavioral state directly. For example, in nocturnal rodents, light is soporific, whereas darkness has activating effects. The direct effects of light on sleep are marked when rats are exposed to short (i.e., 6 hour) light-dark cycles which do not allow circadian entrainment to occur. In these conditions, rats tend to fall asleep acutely following a dark-to-light transition, and to sleep more during the light periods in comparison to the dark periods. Moreover, rapid eye movement (REM) sleep in albino rats is triggered following a light-to-dark transition.

ISBN: 0591954044Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Mechanisms subserving the direct effects of light on sleep in rats.
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245 1 0 $a Mechanisms subserving the direct effects of light on sleep in rats.
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500 $a Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3272.
500 $a Supervisor: Ruth M. Benca.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 1998.
520 $a Patterns of sleep and wakefulness in humans and other mammals are regulated by the light-dark cycle. Light has the ability to entrain the circadian (or 24 hour) pacemaker, and it is also able to influence behavioral state directly. For example, in nocturnal rodents, light is soporific, whereas darkness has activating effects. The direct effects of light on sleep are marked when rats are exposed to short (i.e., 6 hour) light-dark cycles which do not allow circadian entrainment to occur. In these conditions, rats tend to fall asleep acutely following a dark-to-light transition, and to sleep more during the light periods in comparison to the dark periods. Moreover, rapid eye movement (REM) sleep in albino rats is triggered following a light-to-dark transition.
520 $a Since the visual system mediates the direct effects of light on behavioral state, we performed a series of lesion studies in albino rats to determine targets of visual pathways involved in the direct effects of light and darkness on sleep-waking patterns. First we found that aspiration lesions of the superior colliculus-pretectal area, structures which are known to be involved in the control of eye movements, attenuated the ability of light to acutely influence sleep-waking patterns, as well as REM sleep expression. In order to isolate the role of the superior colliculus from that of the pretectum, we made more discrete lesions of either the superior colliculus or the pretectal area using the excitotoxin ibotenic acid. An interesting dissociation occurred as a result of this experiment: lesions of the pretectum affected the ability of light-dark transitions to induce REM sleep in albino rats, but did not eliminate the direct effects of light on sleep and wakefulness. Conversely, lesions of the superior colliculus greatly attenuated the soporific and activating effects of light and dark, but the ability of light-dark transitions to influence REM sleep remained intact. These data are the first to show that the superior colliculus and pretectum are involved in promoting sleep and wakefulness, and the first to identify brain areas involved in mediating the direct effects of light on behavioral state.
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