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Analysis ofperiod transcript structu...

Cheng, Yuzhong.

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Analysis ofperiod transcript structure and function within the Drosophila circadian oscillator.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Analysis ofperiod transcript structure and function within the Drosophila circadian oscillator./
Author:	Cheng, Yuzhong.
Description:	133 p.
Notes:	Source: Dissertation Abstracts International, Volume: 59-04, Section: B, page: 1492.
Contained By:	Dissertation Abstracts International59-04B.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9830885
ISBN:	0591838184

Analysis ofperiod transcript structure and function within the Drosophila circadian oscillator.
Cheng, Yuzhong.

Analysis ofperiod transcript structure and function within the Drosophila circadian oscillator. - 133 p.

Source: Dissertation Abstracts International, Volume: 59-04, Section: B, page: 1492.

Thesis (Ph.D.)--Texas A&M University, 1998.

The period (per) gene encodes a central component of the circadian clock in Drosophila melanogaster. It was reported eleven years ago that per has three types of transcripts (type A, type B and type C) that encode three different proteins. In the first part of this study, per was found to have only two transcripts, type A and type B

ISBN: 0591838184Subjects--Topical Terms:

1017719
Biology, Molecular.

Analysis ofperiod transcript structure and function within the Drosophila circadian oscillator.
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020 $a 0591838184
035 $a (UnM)AAI9830885
035 $a AAI9830885
040 $a UnM $c UnM
100 1 $a Cheng, Yuzhong. $3 1907159
245 1 0 $a Analysis ofperiod transcript structure and function within the Drosophila circadian oscillator.
300 $a 133 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-04, Section: B, page: 1492.
500 $a Co-Chairs: Paul E. Hardin; Vincent M. Cassone.
502 $a Thesis (Ph.D.)--Texas A&M University, 1998.
520 $a The period (per) gene encodes a central component of the circadian clock in Drosophila melanogaster. It was reported eleven years ago that per has three types of transcripts (type A, type B and type C) that encode three different proteins. In the first part of this study, per was found to have only two transcripts, type A and type B $\ sp\prime, $ which differ by the presence of an alternative intron in their 3 $\ sp\prime $ untranslated regions (3 $\ sp\prime $- UTR). Type A and type B $\ sp\prime $ transcripts are found in different tissues with varying ratios, and the levels of these transcripts cycle both in fly heads and bodies with identical phases but different amplitudes. The alternative intron in 3 $\ sp\prime $- UTR of per was found to affect the circadian period of locomotor activity rhythms. Circadian fluctuations in per mRNA and per protein (PER) constitute part of a feedback loop which is required for circadian pacemaker function. PER cycling is required for per RNA cycling, but the converse has not been tested. The feedback loop operates in many tissues but whether it operates autonomously in each tissue is unknown. In the second part of this study, transgenic flies which express wild type levels of per specifically in photoreceptors R1-R6 were generated. Under both light:dark (LD) cycling and constant dark (DD) conditions, per protein (PER) abundance cycles in the absence of circadian cycling of per mRNA. These results show that per mRNA cycling is not required for PER cycling, and indicate that eye photoreceptors R1-R6 contain a tissue autonomous circadian oscillator. One of the transgenic strains generated in this project also expresses PER in eyes and lateral brain neurons (LNs), presumably due to an enhancer-trap. This strain restores locomotor activity rhythms without per mRNA cycling. This result indicates that per mRNA cycling is also not required for locomotor activity rhythms.
590 $a School code: 0803.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0307
690 $a 0369
690 $a 0433
710 2 0 $a Texas A&M University. $3 718977
773 0 $t Dissertation Abstracts International $g 59-04B.
790 1 0 $a Hardin, Paul E., $e advisor
790 1 0 $a Cassone, Vincent M., $e advisor
790 $a 0803
791 $a Ph.D.
792 $a 1998
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9830885