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Pharmacological and electrophysiolog...

Kinney, Gene G.

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Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm./
Author:	Kinney, Gene G.
Description:	130 p.
Notes:	Source: Dissertation Abstracts International, Volume: 55-03, Section: B, page: 0748.
Contained By:	Dissertation Abstracts International55-03B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9421428

Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm.
Kinney, Gene G.

Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm. - 130 p.

Source: Dissertation Abstracts International, Volume: 55-03, Section: B, page: 0748.

Thesis (Ph.D.)--Florida Atlantic University, 1994.

Available evidence suggests that the median raphe nucleus (MRN), when activated, produces a desynchronized hippocampal electroencephalog ram (EEG), and that this effect is sensitive to serotonergic (5-HT) manipulations. Experiment 1 examined the effect of injections into the MRN of agents that non-specifically (procaine) or selectively (8-OH-DPAT and buspirone) inhibit serotonin-containing MRN neurons. These substances produced hippocampal theta rhythm at short latencies and for long durations, suggesting that MRN 5-HT neurons are specifically responsible for controlling the hippocampal EEG. MRN 5-HT neurons are modulated by a facilitatory excitatory amino acid (EAA) input and an inhibitory influence from GABAergic interneurons within the MRN. Experiments 2 and 3 examined the effect of manipulations of these systems on the hippocampal EEG. Experiment 2 demonstrated that injections of the specific (AP-7) and non-specific (MK-801) NMDA antagonists, as well as the kainate/quisqualate antagonist (GAMS) into the MRN produce theta at short latencies and for long durations. Experiment 3 demonstrated that injections of the GABASubjects--Topical Terms:

1017680
Biology, Neuroscience.

Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm.
LDR:03080nmm 2200277 4500 001 1817790
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008 130610s1994 eng d
035 $a (UnM)AAI9421428
035 $a AAI9421428
040 $a UnM $c UnM
100 1 $a Kinney, Gene G. $3 1907136
245 1 0 $a Pharmacological and electrophysiological evidence for a role of the median raphe nucleus in the control of hippocampal theta rhythm.
300 $a 130 p.
500 $a Source: Dissertation Abstracts International, Volume: 55-03, Section: B, page: 0748.
500 $a Adviser: Robert P. Vertes.
502 $a Thesis (Ph.D.)--Florida Atlantic University, 1994.
520 $a Available evidence suggests that the median raphe nucleus (MRN), when activated, produces a desynchronized hippocampal electroencephalog ram (EEG), and that this effect is sensitive to serotonergic (5-HT) manipulations. Experiment 1 examined the effect of injections into the MRN of agents that non-specifically (procaine) or selectively (8-OH-DPAT and buspirone) inhibit serotonin-containing MRN neurons. These substances produced hippocampal theta rhythm at short latencies and for long durations, suggesting that MRN 5-HT neurons are specifically responsible for controlling the hippocampal EEG. MRN 5-HT neurons are modulated by a facilitatory excitatory amino acid (EAA) input and an inhibitory influence from GABAergic interneurons within the MRN. Experiments 2 and 3 examined the effect of manipulations of these systems on the hippocampal EEG. Experiment 2 demonstrated that injections of the specific (AP-7) and non-specific (MK-801) NMDA antagonists, as well as the kainate/quisqualate antagonist (GAMS) into the MRN produce theta at short latencies and for long durations. Experiment 3 demonstrated that injections of the GABA $\ sb{\rm A} $ agonist, muscimol, into the MRN produced hippocampal theta rhythm at short latencies and for long durations. In light of recent evidence suggesting a theta-pacemaker role for numerous brain nuclei, experiment 4 sought to re-examine the role of the medial septum/diagonal band complex (MS/DB) in hippocampal theta rhythm produced by injections of 8-OH-DPAT into the MRN. Four categories of MS/DB neurons were described: (1) cells which burst rhythmically with theta (rhythmical); (2) cells displaying a tonic increase in discharge with theta (theta-on); (3) cells displaying a dramatic decrease or cessation of discharge with theta (theta-off); and (4) cells which showed no changes in discharge in relation to theta (no-change). It was shown that injections of 8-OH-DPAT into the MRN caused a change in discharge of rhythmic MS/DB cells from an irregular non-bursting pattern during baseline conditions to a rhythmical, bursting pattern which was highly coherent with the hippocampal EEG.
590 $a School code: 0119.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0317
690 $a 0419
690 $a 0433
710 2 0 $a Florida Atlantic University. $3 1017837
773 0 $t Dissertation Abstracts International $g 55-03B.
790 1 0 $a Vertes, Robert P., $e advisor
790 $a 0119
791 $a Ph.D.
792 $a 1994
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9421428