東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Synthesis and assembly of DNA-modifi...

Li, Zhi.

Linked to FindBook

Google Book

Amazon

博客來

Synthesis and assembly of DNA-modified nanostructured materials.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis and assembly of DNA-modified nanostructured materials./
Author:	Li, Zhi.
Description:	143 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3127.
Contained By:	Dissertation Abstracts International66-06B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3177761
ISBN:	0542173506

Synthesis and assembly of DNA-modified nanostructured materials.
Li, Zhi.

Synthesis and assembly of DNA-modified nanostructured materials. - 143 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3127.

Thesis (Ph.D.)--Northwestern University, 2005.

This dissertation describes a series of experiments aimed at developing new synthetic methods towards DNA-modified nanostructured materials, and it also explores new schemes for the 'bio-inspired' rational assembly of such materials.

ISBN: 0542173506Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Synthesis and assembly of DNA-modified nanostructured materials.
LDR:03595nmm 2200313 4500 001 1817603
005 20060821091938.5
008 130610s2005 eng d
020 $a 0542173506
035 $a (UnM)AAI3177761
035 $a AAI3177761
040 $a UnM $c UnM
100 1 $a Li, Zhi. $3 1281624
245 1 0 $a Synthesis and assembly of DNA-modified nanostructured materials.
300 $a 143 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3127.
500 $a Adviser: Chad A. Mirkin.
502 $a Thesis (Ph.D.)--Northwestern University, 2005.
520 $a This dissertation describes a series of experiments aimed at developing new synthetic methods towards DNA-modified nanostructured materials, and it also explores new schemes for the 'bio-inspired' rational assembly of such materials.
520 $a In Chapter 2, a novel trithiol-capped oligodeoxyribonucleotide and its related gold nanoparticle conjugates were synthesized. These DNA-gold nanoparticle conjugates exhibit substantially higher stabilities than analogues prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, respectively, but comparable hybridization properties. In addition, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles larger than 30 nm in diameter, which are essential for many diagnostic applications.
520 $a In Chapter 3, a general solid-phase synthetic strategy for producing a novel class of DNA block copolymer amphiphiles is described. The assembled spherical micelle nanostructures exhibit recognition properties defined by their DNA sequences and can also be used to build higher-ordered structures through hybridization with nanomaterials that possess complementary DNA.
520 $a In Chapter 4, the design and synthesis of a new class of gold nanoparticle with guanosine monophosphate derivates or G-rich oligonucleotides as their surface ligands are described. These nanoparticles spontaneously form macroscopic assemblies at low temperature and relatively high salt concentrations, due to the cooperative formation of guanosine quartets and G-quadruplexes between the individual nanoparticles. Significantly, the solution behavior of these nanoparticles is highly controllable by adjusting through solution temperature, ionic strength and the sequence of G-rich oligonucleotide, and the aggregation process was found highly reversible. Since guanosine monophosphate is one of the essential building blocks for DNA, this work provides a deeper understanding of DNA modified nanostructured materials and DNA-nanoparticle probe design.
520 $a Finally, a novel approach of using fungi to template the assembly of pre-synthesized and oligonucleotide-functionalized nanoparticles into ordered structures is reported. Once assembled, secondary structure can be introduced into the living materials, either through hybridization events on the surfaces of the oligonucleotide-functionalized particles or by initiating further fungi growth followed by introduction to a second nanoscale particle building block. This approach allows one to dynamically control the nano-, micro-, and macroscopic architectures of the resulting materials by relying on the fungi as living templates and the nanoparticles as sequence-specific building blocks.
590 $a School code: 0163.
650 4 $a Chemistry, Inorganic. $3 517253
690 $a 0488
710 2 0 $a Northwestern University. $3 1018161
773 0 $t Dissertation Abstracts International $g 66-06B.
790 1 0 $a Mirkin, Chad A., $e advisor
790 $a 0163
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3177761