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Prepubertal exposure to n-3 polyunsa...

Marston, Susan Olivo.

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Prepubertal exposure to n-3 polyunsaturated fatty acids alters mammary tumorigenesis in rats.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Prepubertal exposure to n-3 polyunsaturated fatty acids alters mammary tumorigenesis in rats./
作者:	Marston, Susan Olivo.
面頁冊數:	249 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1694.
Contained By:	Dissertation Abstracts International65-04B.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130002
ISBN:	0496772570

Prepubertal exposure to n-3 polyunsaturated fatty acids alters mammary tumorigenesis in rats.
Marston, Susan Olivo.

Prepubertal exposure to n-3 polyunsaturated fatty acids alters mammary tumorigenesis in rats. - 249 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1694.

Thesis (Ph.D.)--Georgetown University Medical Center, 2004.

The conflicting data examining the association between dietary fat and breast cancer may be caused by the time in which it is studied. Many researchers believe that childhood exposures are very important in determining later breast cancer risk. For these reasons, we wanted to investigate the effects of a prepubertal exposure to polyunsaturated fatty acids (PUFAs) on later breast cancer risk. We exposed rats to low or high fat diets where the fat source was n-3 PUFAs from menhaden oil, or n-6 PUFAs from corn oil, from postnatal day 5 until postnatal day 25. Mammary tumors were initiated via exposure to the carcinogen, 7/12-dimethylbenz[a]anthracene (DMBA) at day 50 and monitored for the next 18 weeks. We demonstrated the ability of a prepubertal exposure to a low fat n-3 PUFA diet to lower mammary tumor incidence, and a prepubertal exposure to a high fat n-3 PUFA diet to increase mammary tumorigenesis.

ISBN: 0496772570Subjects--Topical Terms:

1017719
Biology, Molecular.

Prepubertal exposure to n-3 polyunsaturated fatty acids alters mammary tumorigenesis in rats.
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245 1 0 $a Prepubertal exposure to n-3 polyunsaturated fatty acids alters mammary tumorigenesis in rats.
300 $a 249 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1694.
500 $a Adviser: Leena Hilakivi-Clarke.
502 $a Thesis (Ph.D.)--Georgetown University Medical Center, 2004.
520 $a The conflicting data examining the association between dietary fat and breast cancer may be caused by the time in which it is studied. Many researchers believe that childhood exposures are very important in determining later breast cancer risk. For these reasons, we wanted to investigate the effects of a prepubertal exposure to polyunsaturated fatty acids (PUFAs) on later breast cancer risk. We exposed rats to low or high fat diets where the fat source was n-3 PUFAs from menhaden oil, or n-6 PUFAs from corn oil, from postnatal day 5 until postnatal day 25. Mammary tumors were initiated via exposure to the carcinogen, 7/12-dimethylbenz[a]anthracene (DMBA) at day 50 and monitored for the next 18 weeks. We demonstrated the ability of a prepubertal exposure to a low fat n-3 PUFA diet to lower mammary tumor incidence, and a prepubertal exposure to a high fat n-3 PUFA diet to increase mammary tumorigenesis.
520 $a In addition to establishing the protective effect of a prepubertal low fat n-3 PUFA diet and the promoting effect of a high fat n-3 PUFA diet, we examined the biological changes mediating these effects. Both the low and the high fat diet increased lipid peroxidation, however, animals fed the low fat n-3 PUFA diet had an increased antioxidant response which appeared to prevent the occurrence of DNA damage. Additionally, animals fed the low fat n-3 PUFA diet had increased levels of apoptosis, a pathway that may have helped eliminate damaged cells. Conversely, animals fed the high fat n-3 PUFA diet had a decreased antioxidant response and a subsequent increase in DNA damage. Additionally, because these animals had increased proliferation and decreased apoptosis, the heavily damaged cells may not have been eliminated, but instead continued to grow and form tumors.
520 $a We have demonstrated the ability of a prepubertal high fat n-3 PUFA diet to increase mammary tumorigenesis. Additionally, we have shown this detrimental effect may be caused by the manner in which these animals respond to increased DNA damage. In conclusion, the potentially harmful effects of a childhood diet high in n-3 PUFAs needs to be further researched.
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