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Bactriolytic therapy for cancer.

Bettegowda, Chetan.

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Bactriolytic therapy for cancer.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Bactriolytic therapy for cancer./
作者:	Bettegowda, Chetan.
面頁冊數:	158 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 1992.
Contained By:	Dissertation Abstracts International66-04B.
標題:	Health Sciences, Oncology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3172543
ISBN:	0542100495

Bactriolytic therapy for cancer.
Bettegowda, Chetan.

Bactriolytic therapy for cancer. - 158 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 1992.

Thesis (Ph.D.)--The Johns Hopkins University, 2005.

Nearly one in four adults in Western countries will die as a result of a malignancy. A hallmark of many of these tumors is the presence of areas of hypoxia and necrosis that are often resistant to most standard chemotherapeutic and radiation therapies. We hypothesized that experimental solid tumors can be targeted and treated using anaerobic bacteria that can selectively replicate in areas of low oxygen. Our initial studies on anaerobic bacteria revealed a strain of the bacterium Clostridium novyi (named C. novyi-NT), unique in its ability to localize, germinate and destroy experimental tumors while exhibiting little toxicity. Clostridium novyi-NT could be readily combined with clinically used radiation regimens and chemotherapeutic agents to produce substantial regressions and cures in several tumor models. In order to further understand the basis for C. novyi-NT's ability to destroy tumors we sequenced its 2.55 megabase genome, which yielded 17 secreted proteins and 43 genes involved with pathogenicity that could potentially exert an anti-tumor effect. One of the genes discovered during annotation of the genome was thymdine kinase, a gene exploited for imaging herpes simplex virus (HSV) in vivo. Similar to cells infected with HSV, C. novyi-NT could also be imaged in mice using the radiolabeled isotope 2'-fluoro-2' -deoxy-1-beta-d-arabinofuranosyl-5-125I-iodouracil (125I-FIAU). In silico analyses of all sequenced pathogenic bacteria revealed the presence of a highly conserved thymdine kinase gene in every one of these bacteria. Accordingly, we were able to image six out of six common bacterial pathogens in mice using 125I-FIAU, suggesting that this radiotracer can be used clinically as a bacterial infection imaging agent. The high resolution images obtained suggest that this approach can be readily adapted for imaging bacterial infections in a clinical setting.

ISBN: 0542100495Subjects--Topical Terms:

1018566
Health Sciences, Oncology.

Bactriolytic therapy for cancer.
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