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Anticancer activity of two dietary p...

Merchant, Kendra T.

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Anticancer activity of two dietary phytochemicals: Genistein and beta-lapachone.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Anticancer activity of two dietary phytochemicals: Genistein and beta-lapachone./
Author:	Merchant, Kendra T.
Description:	52 p.
Notes:	Source: Masters Abstracts International, Volume: 43-06, page: 2074.
Contained By:	Masters Abstracts International43-06.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1426985
ISBN:	054213439X

Anticancer activity of two dietary phytochemicals: Genistein and beta-lapachone.
Merchant, Kendra T.

Anticancer activity of two dietary phytochemicals: Genistein and beta-lapachone. - 52 p.

Source: Masters Abstracts International, Volume: 43-06, page: 2074.

Thesis (M.S.)--Florida Atlantic University, 2005.

Phytochemicals are biologically active secondary plant metabolites that have been shown to exhibit anti-cancer activity. The dietary phytochemicals genistein isoflavone and beta-lapachone, were investigated to determine their effect on the growth of human prostate adenocarcinoma cells in vitro. The cells were exposed to varying concentrations of both phytochemicals in single and combination treatments for specified time periods and their effect was determined using post-treatment cell viability, treatment-induced apoptosis and cell signaling assays. The overall results revealed that both phytochemicals inhibited cell growth and proliferation and induced apoptosis in a dose-dependent manner for both single and combination treatments. However, combination treatments were not significantly more effective than single treatment with either drug. Both phytochemicals could therefore offer therapeutic efficacy in human prostate adenocarcinoma.

ISBN: 054213439XSubjects--Topical Terms:

1017686
Biology, Cell.

Anticancer activity of two dietary phytochemicals: Genistein and beta-lapachone.
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100 1 $a Merchant, Kendra T. $3 1904565
245 1 0 $a Anticancer activity of two dietary phytochemicals: Genistein and beta-lapachone.
300 $a 52 p.
500 $a Source: Masters Abstracts International, Volume: 43-06, page: 2074.
500 $a Adviser: James Kumi-Diaka.
502 $a Thesis (M.S.)--Florida Atlantic University, 2005.
520 $a Phytochemicals are biologically active secondary plant metabolites that have been shown to exhibit anti-cancer activity. The dietary phytochemicals genistein isoflavone and beta-lapachone, were investigated to determine their effect on the growth of human prostate adenocarcinoma cells in vitro. The cells were exposed to varying concentrations of both phytochemicals in single and combination treatments for specified time periods and their effect was determined using post-treatment cell viability, treatment-induced apoptosis and cell signaling assays. The overall results revealed that both phytochemicals inhibited cell growth and proliferation and induced apoptosis in a dose-dependent manner for both single and combination treatments. However, combination treatments were not significantly more effective than single treatment with either drug. Both phytochemicals could therefore offer therapeutic efficacy in human prostate adenocarcinoma.
590 $a School code: 0119.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0379
690 $a 0307
690 $a 0992
710 2 0 $a Florida Atlantic University. $3 1017837
773 0 $t Masters Abstracts International $g 43-06.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1426985