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Novel palladium(II) catalysts for as...

El-Qisairi, Arab Khalil.

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Novel palladium(II) catalysts for asymmetric synthesis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Novel palladium(II) catalysts for asymmetric synthesis./
作者:	El-Qisairi, Arab Khalil.
面頁冊數:	171 p.
附註:	Source: Dissertation Abstracts International, Volume: 57-12, Section: B, page: 7521.
Contained By:	Dissertation Abstracts International57-12B.
標題:	Chemistry, Inorganic. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9715234
ISBN:	0591230089

Novel palladium(II) catalysts for asymmetric synthesis.
El-Qisairi, Arab Khalil.

Novel palladium(II) catalysts for asymmetric synthesis. - 171 p.

Source: Dissertation Abstracts International, Volume: 57-12, Section: B, page: 7521.

Thesis (Ph.D.)--Loyola University Chicago, 1997.

The objective of this project is the development of new asymmetric syntheses by chiral palladium catalysts. Several chiral mono and dipalladium(II) catalysts using the monodentate ligands, (R)-(+)-N,N-dimethyl-1-phenethylamine

ISBN: 0591230089Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Novel palladium(II) catalysts for asymmetric synthesis.
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100 1 $a El-Qisairi, Arab Khalil. $3 1903235
245 1 0 $a Novel palladium(II) catalysts for asymmetric synthesis.
300 $a 171 p.
500 $a Source: Dissertation Abstracts International, Volume: 57-12, Section: B, page: 7521.
500 $a Director: Patrick M. Henry.
502 $a Thesis (Ph.D.)--Loyola University Chicago, 1997.
520 $a The objective of this project is the development of new asymmetric syntheses by chiral palladium catalysts. Several chiral mono and dipalladium(II) catalysts using the monodentate ligands, (R)-(+)-N,N-dimethyl-1-phenethylamine $\ { $( R)-DMPA $\ } $, (S)-(+)-neomenthyl diphenylphosphine $\ { $( S)-NMDPP $\ } $ and the bidentate ligands, (1R,2R)-( $- $) -1,2-diaminocyclohexane $\ { $( 1R,2R)-DACH $\ } $, (+)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis-(diphenylphosphino)butane $\ { $( +)-DIOP $\ } $, ( $- $) -2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis-(diphenylphosphino)butane $\ {(- $) -DIOP $\ } $ and (S)-( $- $) -2,2 $\ sp\prime $- bis(diphenylphosphino)-1,1 $\ sp\prime $- binaphthyl $\ { $( S)-BLNAP $\ } $ were prepared and characterized by $\ sp1 $\ sp{13} $\ sp{31} $\ alpha $- olefins with these catalysts were studied under conditions of low (Cl $\ sp- $) and high (CuCl $\ sb2 $) . 1-Chloro-2-hydroxyalkanes (38) were the major product with smaller amounts of 2-chloro-1-hydroxyalkane (39). The highest optical yields for the 1-chloro-2-hydroxy-alkanes were obtained when (+)- or ( $- $) -DIOP and (S)-BINAP were used as bridging ligands. Oxidation of allyl ethers to give chiral chlorohydrins could be a valuable new asymmetric synthesis which would be an alternative to procedures involving the Sharpless epoxidation. Our results with allyl phenyl ether and allyl- $\ alpha $- naphthyl ether indicated that only the 38 isomer is formed. The yields were very high ( $> $9 0%) and the ee's were in the range of 80-93%.
520 $a Oxidation of trans-2-butene and trans-2-pentene with chiral dipalladium(II) catalysts in chloride-free glacial acetic acid gave chiral allylic acetates with ee's of 77-85%. 2-Cyclohexen-1-yl acetate was obtained in a high yield, but the %ee was only 6%.
520 $a The oxidation of several ketones by the bimetallic catalyst 27 in the presence of CuCl $\ sb2 $ gave mainly $\ alpha $- hydroxy ketones. The % ee of the $\ alpha $- hydroxy ketones were in the range of 74%-90%. Since the reaction is an enolization, it would be expected to be acid catalyzed. Methanesulfonic acid was used to accelerate the enolization and the yields did increase dramatically.
520 $a Allylic isomerization studies of crotyl alcohol gave chiral 3-buten-2-ol while isomerization of crotyl acetate, crotyl chloride and trans-2-hexenyl acetate gave chiral allylic acetates. The products were obtained in moderate yields (20%-40%). The ee's of the chiral allylic compounds were in the range of 32%-77%.
590 $a School code: 0112.
650 4 $a Chemistry, Inorganic. $3 517253
650 4 $a Chemistry, Organic. $3 516206
690 $a 0488
690 $a 0490
710 2 0 $a Loyola University Chicago. $3 1020295
773 0 $t Dissertation Abstracts International $g 57-12B.
790 1 0 $a Henry, Patrick M., $e advisor
790 $a 0112
791 $a Ph.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9715234