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A bistable feedback loop of microRNA...

Johnston, Robert J., Jr.

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A bistable feedback loop of microRNAs and transcription factors controls neuronal left/right asymmetry in Caenorhabditis elegans.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A bistable feedback loop of microRNAs and transcription factors controls neuronal left/right asymmetry in Caenorhabditis elegans./
Author:	Johnston, Robert J., Jr.
Description:	188 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0133.
Contained By:	Dissertation Abstracts International66-01B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3159772
ISBN:	0496929186

A bistable feedback loop of microRNAs and transcription factors controls neuronal left/right asymmetry in Caenorhabditis elegans.
Johnston, Robert J., Jr.

A bistable feedback loop of microRNAs and transcription factors controls neuronal left/right asymmetry in Caenorhabditis elegans. - 188 p.

Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0133.

Thesis (Ph.D.)--Columbia University, 2005.

Neuronal diversification along the left/right axis is a critical yet poorly understood developmental process across species. This thesis focuses on the mechanism by which asymmetry is controlled in a bilateral pair of chemosensory neurons, ASE left (ASEL) and ASE right (ASER), in Caenorhabditis elegans . ASEL is the primary sodium sensing neuron whereas ASER is the primary chloride and potassium sensing neuron (Pierce-Shimomura et al., 2001). This functional asymmetry correlates with an asymmetry in gene expression of putative chemoreceptor proteins (Yu et al., 1997). Mutant analysis suggests that the role of ASEL/R diversification is to increase the representational capacity of the nervous system of the worm (Pierce-Shimomura et al., 2001).

ISBN: 0496929186Subjects--Topical Terms:

1017680
Biology, Neuroscience.

A bistable feedback loop of microRNAs and transcription factors controls neuronal left/right asymmetry in Caenorhabditis elegans.
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035 $a (UnM)AAI3159772
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100 1 $a Johnston, Robert J., Jr. $3 1902240
245 1 2 $a A bistable feedback loop of microRNAs and transcription factors controls neuronal left/right asymmetry in Caenorhabditis elegans.
300 $a 188 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0133.
500 $a Adviser: Oliver Hobert.
502 $a Thesis (Ph.D.)--Columbia University, 2005.
520 $a Neuronal diversification along the left/right axis is a critical yet poorly understood developmental process across species. This thesis focuses on the mechanism by which asymmetry is controlled in a bilateral pair of chemosensory neurons, ASE left (ASEL) and ASE right (ASER), in Caenorhabditis elegans . ASEL is the primary sodium sensing neuron whereas ASER is the primary chloride and potassium sensing neuron (Pierce-Shimomura et al., 2001). This functional asymmetry correlates with an asymmetry in gene expression of putative chemoreceptor proteins (Yu et al., 1997). Mutant analysis suggests that the role of ASEL/R diversification is to increase the representational capacity of the nervous system of the worm (Pierce-Shimomura et al., 2001).
520 $a This thesis provides evidence that the ASEL/R cell fate decision is a bistable system in that an ASE cell must become one of the two alternate cell fates. The ASE cells proceed through a hybrid precursor state and then refine and stabilize expression to a stereotypical ASEL or ASER gene expression profile. This bistable system is controlled by a regulatory feedback loop that involves the miRNAs, lsy-6 and mir-273, and their respective transcription factor target genes, cog-1 and die-1. In addition to these asymmetry inducing genes, several permissive factors, including ceh-36, lin-49, unc-37, and lsy-2 are required for proper establishment of ASEL/R asymmetry.
520 $a In this thesis, miRNAs and transcription factors are identified and characterized to play a role in the determination of ASEL/R cell fate. This characterization also provides novel insights into the role of miRNAs in neuronal development and cell specific fate determination, spatial regulation of miRNAs, miRNA-mediated regulation of other miRNAs via transcription factors, and maintenance of expression of miRNA and transcription factors via feedback regulatory loops.
590 $a School code: 0054.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
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710 2 0 $a Columbia University. $3 571054
773 0 $t Dissertation Abstracts International $g 66-01B.
790 1 0 $a Hobert, Oliver, $e advisor
790 $a 0054
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3159772