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Spatial organization in kinetic mode...

Maly, Ivan Viktorovich.

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Spatial organization in kinetic models of the cytoskeleton and cell motility.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Spatial organization in kinetic models of the cytoskeleton and cell motility./
Author:	Maly, Ivan Viktorovich.
Description:	129 p.
Notes:	Source: Dissertation Abstracts International, Volume: 63-11, Section: B, page: 5015.
Contained By:	Dissertation Abstracts International63-11B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3071677
ISBN:	0493916512

Spatial organization in kinetic models of the cytoskeleton and cell motility.
Maly, Ivan Viktorovich.

Spatial organization in kinetic models of the cytoskeleton and cell motility. - 129 p.

Source: Dissertation Abstracts International, Volume: 63-11, Section: B, page: 5015.

Thesis (Ph.D.)--Northwestern University, 2002.

The functional structure of biological cells is largely determined by the cytoskeleton and by the motility that is driven and guided by the cytoskeleton. The recently accumulated empiric knowledge of the dynamics of the cytoskeleton and cytoskeleton-based motility requires theoretical analysis for a systematic knowledge representation, interpretation and also to provide a framework for future experimental research. In this dissertation, kinetic models of cytoskeleton dynamics and related motility phenomena are formulated and analyzed to derive the spatial organization of the cell and its components from the kinetics of the molecular processes involved. Several phenomena are studied that are mechanistically connected and can be studied by using similar theoretical approaches. It is demonstrated that the simple diffusion approximation of the stochastic processes of the microtubule assembly and the microtubule-based intracellular transport is valid under the experimentally studied conditions. This demonstration employs such theoretical advances as the prediction for the distribution of the lifetime of microtubule segments at different positions in the cell, the inference of the asymptotic diffusion parameters for an arbitrary one-dimensional velocity jump process, and the formulation of a detailed model of lipid transport in Drosophila embryos. The spontaneous emergence of the functional orientation of microtubules in the absence of the centrosome is explained as a steady-state property of the microtubule dynamics that takes place under these conditions and is called treadmilling. Orientation of actin filaments whose elongation propels cellular protrusions in the course of the cell locomotion is also explained based on the kinetics and geometry of initiation and termination of the filament growth that reach steady state through a process identical to Darwinian natural selection. Together, the kinetic models analyzed in this dissertation facilitate systematic understanding of the cytoskeleton-related aspects of the spatial organization of the cell.

ISBN: 0493916512Subjects--Topical Terms:

1017686
Biology, Cell.

Spatial organization in kinetic models of the cytoskeleton and cell motility.
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100 1 $a Maly, Ivan Viktorovich. $3 1901239
245 1 0 $a Spatial organization in kinetic models of the cytoskeleton and cell motility.
300 $a 129 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-11, Section: B, page: 5015.
500 $a Adviser: Gary G. Borisy.
502 $a Thesis (Ph.D.)--Northwestern University, 2002.
520 $a The functional structure of biological cells is largely determined by the cytoskeleton and by the motility that is driven and guided by the cytoskeleton. The recently accumulated empiric knowledge of the dynamics of the cytoskeleton and cytoskeleton-based motility requires theoretical analysis for a systematic knowledge representation, interpretation and also to provide a framework for future experimental research. In this dissertation, kinetic models of cytoskeleton dynamics and related motility phenomena are formulated and analyzed to derive the spatial organization of the cell and its components from the kinetics of the molecular processes involved. Several phenomena are studied that are mechanistically connected and can be studied by using similar theoretical approaches. It is demonstrated that the simple diffusion approximation of the stochastic processes of the microtubule assembly and the microtubule-based intracellular transport is valid under the experimentally studied conditions. This demonstration employs such theoretical advances as the prediction for the distribution of the lifetime of microtubule segments at different positions in the cell, the inference of the asymptotic diffusion parameters for an arbitrary one-dimensional velocity jump process, and the formulation of a detailed model of lipid transport in Drosophila embryos. The spontaneous emergence of the functional orientation of microtubules in the absence of the centrosome is explained as a steady-state property of the microtubule dynamics that takes place under these conditions and is called treadmilling. Orientation of actin filaments whose elongation propels cellular protrusions in the course of the cell locomotion is also explained based on the kinetics and geometry of initiation and termination of the filament growth that reach steady state through a process identical to Darwinian natural selection. Together, the kinetic models analyzed in this dissertation facilitate systematic understanding of the cytoskeleton-related aspects of the spatial organization of the cell.
590 $a School code: 0163.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biophysics, General. $3 1019105
690 $a 0379
690 $a 0786
710 2 0 $a Northwestern University. $3 1018161
773 0 $t Dissertation Abstracts International $g 63-11B.
790 1 0 $a Borisy, Gary G., $e advisor
790 $a 0163
791 $a Ph.D.
792 $a 2002
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