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The effect of zoledronic acid on an ...

Rieff, Joel Edward.

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The effect of zoledronic acid on an animal model of osteoarthritis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The effect of zoledronic acid on an animal model of osteoarthritis./
作者:	Rieff, Joel Edward.
面頁冊數:	61 p.
附註:	Source: Masters Abstracts International, Volume: 40-05, page: 1180.
Contained By:	Masters Abstracts International40-05.
標題:	Biology, Anatomy. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1408411
ISBN:	0493581677

The effect of zoledronic acid on an animal model of osteoarthritis.
Rieff, Joel Edward.

The effect of zoledronic acid on an animal model of osteoarthritis. - 61 p.

Source: Masters Abstracts International, Volume: 40-05, page: 1180.

Thesis (M.S.)--Rush University, 2002.

Objective. To determine the effect of bone remodeling inhibition by zoledronic acid (ZA) on articular cartilage in a more naturally occurring model of Osteoarthritis (OA), employing anterior cruciate ligament transection (ACLT), in the rabbit knee joint.

ISBN: 0493581677Subjects--Topical Terms:

1021727
Biology, Anatomy.

The effect of zoledronic acid on an animal model of osteoarthritis.
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100 1 $a Rieff, Joel Edward. $3 1900893
245 1 4 $a The effect of zoledronic acid on an animal model of osteoarthritis.
300 $a 61 p.
500 $a Source: Masters Abstracts International, Volume: 40-05, page: 1180.
500 $a Director: Carol Muehleman.
502 $a Thesis (M.S.)--Rush University, 2002.
520 $a Objective. To determine the effect of bone remodeling inhibition by zoledronic acid (ZA) on articular cartilage in a more naturally occurring model of Osteoarthritis (OA), employing anterior cruciate ligament transection (ACLT), in the rabbit knee joint.
520 $a Design. New Zealand White male rabbits were divided into four groups: (1) ACLT surgery; (2) ACLT surgery with subcutaneous ZA injections; (3) sham surgery with subcutaneous ZA injections; (4) sham surgery. Animals were sacrificed after 12-weeks.
520 $a Results. Tibial plateaus were the only articular surface displaying gross degeneration (2 of 25 animals) after ACLT surgery. Macroscopically, no significant differences were determined between the four groups. However, microscopic degeneration was observed in tissue of ACLT animals previously determined as macroscopically normal. A possible trend was determined between the four groups.
520 $a Conclusion. ZA demonstrated a potential trend toward a chondroprotective effect in a rabbit ACLT model of OA.
590 $a School code: 0821.
650 4 $a Biology, Anatomy. $3 1021727
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0287
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710 2 0 $a Rush University. $3 1261752
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790 1 0 $a Muehleman, Carol, $e advisor
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791 $a M.S.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1408411