東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Susceptibility of simian immunodefic...

Giuffre, Angelica Christine.

Linked to FindBook

Google Book

Amazon

博客來

Susceptibility of simian immunodeficiency virus to protease inhibitors and mutations that confer drug resistance.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Susceptibility of simian immunodeficiency virus to protease inhibitors and mutations that confer drug resistance./
Author:	Giuffre, Angelica Christine.
Description:	134 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1142.
Contained By:	Dissertation Abstracts International65-03B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3126610
ISBN:	0496738909

Susceptibility of simian immunodeficiency virus to protease inhibitors and mutations that confer drug resistance.
Giuffre, Angelica Christine.

Susceptibility of simian immunodeficiency virus to protease inhibitors and mutations that confer drug resistance. - 134 p.

Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1142.

Thesis (Ph.D.)--University of California, Davis, 2004.

Several projects were undertaken to compare simian immunodeficiency virus (SIV) to human immunodeficiency virus type-1 (HIV-1) in susceptibility to protease inhibitors and to study protease inhibitor resistance. The first study used a quantitative focal infectivity assay to directly compare the susceptibilities of SIV and HIV-1 in the same cell line. We examined the susceptibilities of SIV to three FDA approved protease inhibitors, indinavir, ritonavir, and saquinavir. SIV is similar to HIV-1 in susceptibility to these three protease inhibitors.

ISBN: 0496738909Subjects--Topical Terms:

1017734
Biology, Microbiology.

Susceptibility of simian immunodeficiency virus to protease inhibitors and mutations that confer drug resistance.
LDR:03060nmm 2200301 4500 001 1811250
005 20051203081809.5
008 130610s2004 eng d
020 $a 0496738909
035 $a (UnM)AAI3126610
035 $a AAI3126610
040 $a UnM $c UnM
100 1 $a Giuffre, Angelica Christine. $3 1900838
245 1 0 $a Susceptibility of simian immunodeficiency virus to protease inhibitors and mutations that confer drug resistance.
300 $a 134 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1142.
500 $a Adviser: Thomas W. North.
502 $a Thesis (Ph.D.)--University of California, Davis, 2004.
520 $a Several projects were undertaken to compare simian immunodeficiency virus (SIV) to human immunodeficiency virus type-1 (HIV-1) in susceptibility to protease inhibitors and to study protease inhibitor resistance. The first study used a quantitative focal infectivity assay to directly compare the susceptibilities of SIV and HIV-1 in the same cell line. We examined the susceptibilities of SIV to three FDA approved protease inhibitors, indinavir, ritonavir, and saquinavir. SIV is similar to HIV-1 in susceptibility to these three protease inhibitors.
520 $a RT-SHIV (a SIV/HIV chimera with a SIVmac239 backbone and the replacement of the SIV reverse transcriptase with that of HIV-1) is also similar to HIV-1 in susceptibility to indinavir, ritonavir, and saquinavir. Because SIV is not susceptible to non-nucleoside reverse transcriptase inhibitors (NNRTIs), another class of antiretroviral drugs, the RT-SHIV must be used in the rhesus macaque model in order to study drug therapies including the NNRTIs. Using this model, highly active antiretroviral therapy (HAART), including both protease inhibitors and NNRTIs, can be given exactly as it is prescribed to HIV-1 infected patients.
520 $a The second accomplishment of this work was the selection and characterization of SIV mutants resistant to protease inhibitors. Serial passage of SIV was undertaken in the presence of indinavir, nelfinavir, or ritonavir, to select for protease inhibitor-resistance mutations. A unique indinavir mutation of the SIV protease-encoding region, V62A, was revealed. Two of three ritonavir selections yielded virus that were 42-fold resistant to SIV, but did not contain mutations in the protease-encoding region. These two viruses did contain mutations in PBS and in env. Many of the SIV protease inhibitor-resistance mutations are in near proximity to HIV-1 mutations that confer resistance.
520 $a SIVmac239Delta152nef and several other defined SIV Nef mutants were observed to be resistant to protease inhibitors. Although the mechanism of resistance was not determined, this study suggests an association between protease and Nef.
590 $a School code: 0029.
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0410
710 2 0 $a University of California, Davis. $3 1018682
773 0 $t Dissertation Abstracts International $g 65-03B.
790 1 0 $a North, Thomas W., $e advisor
790 $a 0029
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3126610