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The role of inducible nitric oxide s...

Cheng, Xing.

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The role of inducible nitric oxide synthase (iNOS) on cardiovascular function in rats with streptozotocin-induced diabetes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The role of inducible nitric oxide synthase (iNOS) on cardiovascular function in rats with streptozotocin-induced diabetes./
作者:	Cheng, Xing.
面頁冊數:	133 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1262.
Contained By:	Dissertation Abstracts International65-03B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ90160
ISBN:	0612901602

The role of inducible nitric oxide synthase (iNOS) on cardiovascular function in rats with streptozotocin-induced diabetes.
Cheng, Xing.

The role of inducible nitric oxide synthase (iNOS) on cardiovascular function in rats with streptozotocin-induced diabetes. - 133 p.

Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1262.

Thesis (Ph.D.)--The University of British Columbia (Canada), 2004.

Cardiovascular complications are leading causes of death in Type 1 and Type 2 diabetes mellitus. Experimental studies and clinical trials have firmly established a link between hyperglycemia and cardiovascular complications. The precise mechanism involved, however, remains elusive. Recently, inducible nitric oxide synthase (iNOS) and oxidative stress have been implicated as factors that initiate cardiovascular complications in diabetes. However, there is a lack of direct evidence that link these biological changes with abnormalities in cardiovascular function.

ISBN: 0612901602Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

The role of inducible nitric oxide synthase (iNOS) on cardiovascular function in rats with streptozotocin-induced diabetes.
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245 1 4 $a The role of inducible nitric oxide synthase (iNOS) on cardiovascular function in rats with streptozotocin-induced diabetes.
300 $a 133 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-03, Section: B, page: 1262.
500 $a Adviser: Catherine C. Y. Pang.
502 $a Thesis (Ph.D.)--The University of British Columbia (Canada), 2004.
520 $a Cardiovascular complications are leading causes of death in Type 1 and Type 2 diabetes mellitus. Experimental studies and clinical trials have firmly established a link between hyperglycemia and cardiovascular complications. The precise mechanism involved, however, remains elusive. Recently, inducible nitric oxide synthase (iNOS) and oxidative stress have been implicated as factors that initiate cardiovascular complications in diabetes. However, there is a lack of direct evidence that link these biological changes with abnormalities in cardiovascular function.
520 $a The three primary goals of the present investigation were: (1) to investigate if rats with streptozotocin (STZ, 60 mg/kg i.v.)-induced Type 1 diabetes had functional abnormalities of the cardiovascular system, and if these changes were associated with the activation of iNOS, formation of peroxynitrite, and reduced myocardium antioxidant capacity; (2) to examine if treatment with 1400W (inhibitor of iNOS) improved cardiovascular response to noradrenaline (NA) concurrently with inhibition of the activation of iNOS and formation of peroxynitrite in diabetes; (3) to examine if the chronic treatment of the antioxidant N-acetylcysteine (NAC, antioxidant and inhibitor of iNOS) reduced activation of iNOS, decreased formation of peroxynitrite, increased antioxidative capacity, and improved cardiac contractile function in diabetes.
520 $a The results show that diabetic and control rats had similar mean arterial pressure (MAP) and total peripheral resistance (TPR) at three weeks after injection of STZ. NA increased in vivo MAP and TPR in both groups; however, the responses were markedly less in the diabetic than control rats. Rats with diabetes, relative to the controls, had reduced potency (increased ED50) for the pressor (2.5-fold of control) and mean circulatory filling pressure (MCFP, an index of venous tone, 4.3-fold of control) response to NA, as well as reduced maximum pressor response (efficacy) to NA. Diabetic rats also had reduced potency (ED50, 5-fold of control) of the pressor response to angiotensin II. Therefore, arterial and venous constrictions are impaired at an early phase of STZ-induced Type I diabetes.
520 $a The diabetic rats in the present study also had reduced heart rate (HR) and maximal rate of increase as well as decrease of left ventricular pressure (+/-dP/dt of LV) relative to the controls at three weeks after injection of STZ. In addition, the diabetic rats had reduced inotropic and chronotropic responses to NA and dobutamine (beta1-adrenoceptor agonist), exemplified by the decreases in the efficacy (reduced Emax) and potency (increased EC50) of HR, and left ventricular developed tension as well as contractility (+/-dP/dt of LV) responses to dobutamine. (Abstract shortened by UMI.)
590 $a School code: 2500.
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
710 2 0 $a The University of British Columbia (Canada). $3 626643
773 0 $t Dissertation Abstracts International $g 65-03B.
790 1 0 $a Pang, Catherine C. Y., $e advisor
790 $a 2500
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ90160