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Confocal analysis of synaptic connec...

Li, Wei.

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Confocal analysis of synaptic connectivity of the rod pathway in the rabbit retina.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Confocal analysis of synaptic connectivity of the rod pathway in the rabbit retina./
Author:	Li, Wei.
Description:	251 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0566.
Contained By:	Dissertation Abstracts International64-02B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3081467
ISBN:	0496293397

Confocal analysis of synaptic connectivity of the rod pathway in the rabbit retina.
Li, Wei.

Confocal analysis of synaptic connectivity of the rod pathway in the rabbit retina. - 251 p.

Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0566.

Thesis (Ph.D.)--The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, 2003.

The retina is a specialized neuronal structure that transforms the optical image into electrical signals which are transmitted to the brain via the optic nerve. As part of the strategy to cover a stimulus range as broad as 10 log units, from dim starlight to bright sunlight, retinal circuits are broadly divided into rod and cone pathways, responsible for dark and light-adapted vision, respectively.

ISBN: 0496293397Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Confocal analysis of synaptic connectivity of the rod pathway in the rabbit retina.
LDR:03303nmm 2200301 4500 001 1811221
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020 $a 0496293397
035 $a (UnM)AAI3081467
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100 1 $a Li, Wei. $3 884990
245 1 0 $a Confocal analysis of synaptic connectivity of the rod pathway in the rabbit retina.
300 $a 251 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0566.
500 $a Supervisor: Stephen C. Massey.
502 $a Thesis (Ph.D.)--The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, 2003.
520 $a The retina is a specialized neuronal structure that transforms the optical image into electrical signals which are transmitted to the brain via the optic nerve. As part of the strategy to cover a stimulus range as broad as 10 log units, from dim starlight to bright sunlight, retinal circuits are broadly divided into rod and cone pathways, responsible for dark and light-adapted vision, respectively.
520 $a In this dissertation, confocal microscopy and immunocytochemical methods were combined to study the synaptic connectivity of the rod pathway from the level of individual synapses to whole populations of neurons. The study was focused on synaptic interactions at the rod bipolar terminal. The purpose is to understand the synaptic structure of the dyad synapse made by rod bipolar terminals, including the synaptic components and connections, and their physiological functions in the rod pathway. In addition, some additional components and connections of the rod pathway were also studied in these experiments. The major results can be summarized as following: At the dyad synapse of rod bipolar terminals, three postsynaptic components---processes of All amacrine cells and the varicosities of S1 or S2 amacrine cells express different glutamate receptor subunits, which may underlie the functional diversity of these postsynaptic neurons. A reciprocal feedback system is formed by rod bipolar terminals and S1/S2 amacrine cells. Analysis showed these two wide-field GABA amacrine cells have stereotyped synaptic connections with the appropriate morphology and distribution to perform specific functions. In addition, S1 and S2 cells have different coupling patterns and, in general, there is no coupling between the two types. Besides the classic rod pathway though rod bipolar cells and All amacrine cells, the finding of direct connections between certain types of OFF cone bipolar cells and rods indicates the presence of an alternative rod pathway in the rabbit retina.
520 $a In summary, this dissertation presents a detailed view of the connection and receptors at rod bipolar terminals. Based on the morphology, distribution and coupling, different functional roles were identified for S1 and S2 amacrine cells. Finally, an alternative to the classic rod pathway was found in the rabbit retina.
590 $a School code: 2034.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Cell. $3 1017686
690 $a 0317
690 $a 0379
710 2 0 $a The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences. $3 1251166
773 0 $t Dissertation Abstracts International $g 64-02B.
790 1 0 $a Massey, Stephen C., $e advisor
790 $a 2034
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3081467