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Molecular and genetic regulation of ...

Myers, Dina Carole.

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Molecular and genetic regulation of convergence and extension in zebrafish.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular and genetic regulation of convergence and extension in zebrafish./
Author:	Myers, Dina Carole.
Description:	227 p.
Notes:	Source: Dissertation Abstracts International, Volume: 63-01, Section: B, page: 0061.
Contained By:	Dissertation Abstracts International63-01B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3038827
ISBN:	0493518916

Molecular and genetic regulation of convergence and extension in zebrafish.
Myers, Dina Carole.

Molecular and genetic regulation of convergence and extension in zebrafish. - 227 p.

Source: Dissertation Abstracts International, Volume: 63-01, Section: B, page: 0061.

Thesis (Ph.D.)--Vanderbilt University, 2001.

During vertebrate gastrulation the cell movements of convergence and extension mediolaterally narrow and anteroposteriorly lengthen the forming embryonic axis concurrent with the acquisition of cell fate. Patterning molecules direct both of these yet we know little of how they are coordinated. What genetic pathways underlie the movements is also unknown. To study convergence and extension I use the zebrafish, due to the optical transparency of the embryo and the presence of a number of mutants exhibiting gastrulation defects.

ISBN: 0493518916Subjects--Topical Terms:

1017730
Biology, Genetics.

Molecular and genetic regulation of convergence and extension in zebrafish.
LDR:02683nmm 2200289 4500 001 1810440
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020 $a 0493518916
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040 $a UnM $c UnM
100 1 $a Myers, Dina Carole. $3 1900051
245 1 0 $a Molecular and genetic regulation of convergence and extension in zebrafish.
300 $a 227 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-01, Section: B, page: 0061.
500 $a Director: Lilianna Solnica-Krezel.
502 $a Thesis (Ph.D.)--Vanderbilt University, 2001.
520 $a During vertebrate gastrulation the cell movements of convergence and extension mediolaterally narrow and anteroposteriorly lengthen the forming embryonic axis concurrent with the acquisition of cell fate. Patterning molecules direct both of these yet we know little of how they are coordinated. What genetic pathways underlie the movements is also unknown. To study convergence and extension I use the zebrafish, due to the optical transparency of the embryo and the presence of a number of mutants exhibiting gastrulation defects.
520 $a Our work reveals three domains of convergence and extension within the wild-type zebrafish gastrula. Ventrally, cells migrate vegetally to the tailbud. Laterally, cells move with increasing speed towards dorsal. Dorsally, we correlate high levels of extension with mediolateral cell polarization <italic>in vivo </italic>. We characterized the convergence and extension defects in two mutants specifically affected in these processes, <italic>trilobite</italic> and <italic> knypek</italic>. We propose <italic>trilobite</italic> function is needed for the acceleration of convergence and extension movements in the lateral domain whereas Knypek, which potentiates Wnt11 signaling, is required for the dorsal cell polarization. The Bmp activity gradient specifies the C&E movement domains, in addition to directing cell fate specification along the dorso-ventral axis. It does so in part by cell autonomous regulation of cell behavior as well as downregulating secreted dorsal factors that promote C&E without affecting cell fates, <italic>wnt11</italic> and <italic>wnt5</italic>. Therefore we propose that a single gradient of Bmp activity can regulate both cell movements and, possibly in parallel, cell fate specification.
590 $a School code: 0242.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0369
690 $a 0307
710 2 0 $a Vanderbilt University. $3 1017501
773 0 $t Dissertation Abstracts International $g 63-01B.
790 1 0 $a Solnica-Krezel, Lilianna, $e advisor
790 $a 0242
791 $a Ph.D.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3038827