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Statistical models for analyzing hum...

Sankararaman, Sriram.

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Statistical models for analyzing human genetic variation.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Statistical models for analyzing human genetic variation./
作者:	Sankararaman, Sriram.
面頁冊數:	164 p.
附註:	Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5588.
Contained By:	Dissertation Abstracts International71-09B.
標題:	Statistics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3413553
ISBN:	9781124142562

Statistical models for analyzing human genetic variation.
Sankararaman, Sriram.

Statistical models for analyzing human genetic variation. - 164 p.

Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5588.

Thesis (Ph.D.)--University of California, Berkeley, 2010.

Advances in sequencing and genomic technologies are providing new opportunities to understand the genetic basis of phenotypes such as diseases. Translating the large volumes of heterogeneous, often noisy, data into biological insights presents challenging problems of statistical inference. In this thesis, we focus on three important statistical problems that arise in our efforts to understand the genetic basis of phenotypic variation in humans.

ISBN: 9781124142562Subjects--Topical Terms:

517247
Statistics.

Statistical models for analyzing human genetic variation.
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500 $a Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5588.
500 $a Adviser: Michael I. Jordan.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2010.
520 $a Advances in sequencing and genomic technologies are providing new opportunities to understand the genetic basis of phenotypes such as diseases. Translating the large volumes of heterogeneous, often noisy, data into biological insights presents challenging problems of statistical inference. In this thesis, we focus on three important statistical problems that arise in our efforts to understand the genetic basis of phenotypic variation in humans.
520 $a At the molecular level, we focus on the problem of identifying the amino acid residues in a protein that are important for its function. Identifying functional residues is essential to understanding the effect of genetic variation on protein function as well as to understanding protein function itself. We propose computational methods that predict functional residues using evolutionary information as well as from a combination of evolutionary and structural information. We demonstrate that these methods can accurately predict catalytic residues in enzymes. Case studies on well-studied enzymes show that these methods can be useful in guiding future experiments.
520 $a At the population level, discovering the link between genetic and phenotypic variation requires an understanding of the genetic structure of human populations. A common form of population structure is that found in admixed groups formed by the intermixing of several ancestral populations, such as African-Americans and Latinos. We describe a Bayesian hidden Markov model of admixture and propose efficient algorithms to infer the fine-scale structure of admixed populations. We show that the fine-scale structure of these populations can be inferred even when the ancestral populations are unknown or extinct. Further, the inference algorithm can run efficiently on genome-scale datasets. This model is well-suited to estimate other parameters of biological interest such as the allele frequencies of ancestral populations which can be used, in turn, to reconstruct extinct populations.
520 $a Finally, we address the problem of sharing genomic data while preserving the privacy of individual participants. We analyze the problem of detecting an individual genotype from the summary statistics of single nucleotide polymorphisms (SNPs) released in a study. We derive upper bounds on the power of detection as a function of the study size, number of exposed SNPs and the false positive rate, thereby providing guidelines as to which set of SNPs can be safely exposed.
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790 1 0 $a Karp, Richard $e committee member
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791 $a Ph.D.
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