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The regulation of RANK and RANKL mRN...

Praetorius, Lisa J.

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The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c)./
Author:	Praetorius, Lisa J.
Description:	95 p.
Notes:	Source: Masters Abstracts International, Volume: 48-04, page: 2130.
Contained By:	Masters Abstracts International48-04.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR57842
ISBN:	9780494578421

The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).
Praetorius, Lisa J.

The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c). - 95 p.

Source: Masters Abstracts International, Volume: 48-04, page: 2130.

Thesis (M.Sc.)--University of Ontario Institute of Technology (Canada), 2009.

The receptor activator of nuclear factor-kappaB (RANK) and its ligand, RANKL has have been implicated as an important link between breast cancer and metastasis to bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The JAK/STAT5a cell signaling pathway is also crucial to breast biology and is involved in transcriptional regulation of many genes. The objective of this study is to determine if RANKL mRNA expression is regulated through the JAK/STAT5a pathway by stimulating human breast cancer cell lines, MCF-7 and MDA-MB-231, with prolactin (PRL), epidermal growth factor (EGF) and heregulin-beta1 (HRG-beta1), all known to activate STAT5a and play a role in breast cancer progression. This study shows that RANKL expression is upregulated by PRL, EGF and HRG-beta1, and that PRL and HRG-beta1 regulate transcription through the JAK/STAT5a pathway.

ISBN: 9780494578421Subjects--Topical Terms:

1017719
Biology, Molecular.

The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).
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020 $a 9780494578421
035 $a (UMI)AAIMR57842
035 $a AAIMR57842
040 $a UMI $c UMI
100 1 $a Praetorius, Lisa J. $3 1682879
245 1 4 $a The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).
300 $a 95 p.
500 $a Source: Masters Abstracts International, Volume: 48-04, page: 2130.
502 $a Thesis (M.Sc.)--University of Ontario Institute of Technology (Canada), 2009.
520 $a The receptor activator of nuclear factor-kappaB (RANK) and its ligand, RANKL has have been implicated as an important link between breast cancer and metastasis to bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The JAK/STAT5a cell signaling pathway is also crucial to breast biology and is involved in transcriptional regulation of many genes. The objective of this study is to determine if RANKL mRNA expression is regulated through the JAK/STAT5a pathway by stimulating human breast cancer cell lines, MCF-7 and MDA-MB-231, with prolactin (PRL), epidermal growth factor (EGF) and heregulin-beta1 (HRG-beta1), all known to activate STAT5a and play a role in breast cancer progression. This study shows that RANKL expression is upregulated by PRL, EGF and HRG-beta1, and that PRL and HRG-beta1 regulate transcription through the JAK/STAT5a pathway.
520 $a Keywords. RANKL, STAT5, breast cancer, prolactin, epidermal growth factor, heregulin
590 $a School code: 1555.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0307
690 $a 0379
690 $a 0992
710 2 $a University of Ontario Institute of Technology (Canada). $3 1057491
773 0 $t Masters Abstracts International $g 48-04.
790 $a 1555
791 $a M.Sc.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR57842