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Instrumentation for interstitial pho...

Liu, Weiyang.

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Instrumentation for interstitial photodynamic therapy of prostatic carcinoma.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Instrumentation for interstitial photodynamic therapy of prostatic carcinoma./
Author:	Liu, Weiyang.
Description:	184 p.
Notes:	Source: Masters Abstracts International, Volume: 48-04, page: 2407.
Contained By:	Masters Abstracts International48-04.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR56662
ISBN:	9780494566626

Instrumentation for interstitial photodynamic therapy of prostatic carcinoma.
Liu, Weiyang.

Instrumentation for interstitial photodynamic therapy of prostatic carcinoma. - 184 p.

Source: Masters Abstracts International, Volume: 48-04, page: 2407.

Thesis (M.Sc.)--University of Alberta (Canada), 2010.

This thesis encompasses the development and testing of an interstitial photodynamic therapy (iPDT) system for the treatment of prostate cancer. It begins with the optical characterization of a novel photosensitizer (SL-052) followed by a study of tissue optics as it applies to iPDT. The design and integration of a time-fractionated light delivery system with real-time spectral detection is then examined. An optical phantom test medium is formulated and in vitro system operation and testing is performed. Finally, in vivo experiments are performed on animal models with a focus on canine prostate iPDT. Unique optical results with dosimetric relevance are discovered and investigated. This includes metrics for optically measuring local in vivo SL-052 concentrations in real-time as well as novel oscillatory drug photobleaching and recovery behavior during time-fractionated light delivery.

ISBN: 9780494566626Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Instrumentation for interstitial photodynamic therapy of prostatic carcinoma.
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100 1 $a Liu, Weiyang. $3 1682877
245 1 0 $a Instrumentation for interstitial photodynamic therapy of prostatic carcinoma.
300 $a 184 p.
500 $a Source: Masters Abstracts International, Volume: 48-04, page: 2407.
502 $a Thesis (M.Sc.)--University of Alberta (Canada), 2010.
520 $a This thesis encompasses the development and testing of an interstitial photodynamic therapy (iPDT) system for the treatment of prostate cancer. It begins with the optical characterization of a novel photosensitizer (SL-052) followed by a study of tissue optics as it applies to iPDT. The design and integration of a time-fractionated light delivery system with real-time spectral detection is then examined. An optical phantom test medium is formulated and in vitro system operation and testing is performed. Finally, in vivo experiments are performed on animal models with a focus on canine prostate iPDT. Unique optical results with dosimetric relevance are discovered and investigated. This includes metrics for optically measuring local in vivo SL-052 concentrations in real-time as well as novel oscillatory drug photobleaching and recovery behavior during time-fractionated light delivery.
590 $a School code: 0351.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Electronics and Electrical. $3 626636
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0541
690 $a 0544
690 $a 0992
710 2 $a University of Alberta (Canada). $3 626651
773 0 $t Masters Abstracts International $g 48-04.
790 $a 0351
791 $a M.Sc.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR56662