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Abelson family kinases regulate acti...

Talaei, Nafiseh.

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Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration./
Author:	Talaei, Nafiseh.
Description:	129 p.
Notes:	Source: Masters Abstracts International, Volume: 48-02, page: 0984.
Contained By:	Masters Abstracts International48-02.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR52687
ISBN:	9780494526873

Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration.
Talaei, Nafiseh.

Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration. - 129 p.

Source: Masters Abstracts International, Volume: 48-02, page: 0984.

Thesis (M.Sc.)--University of Toronto (Canada), 2009.

The Abelson family protein tyrosine kinases (Abl-PTKs) consist of c-Abl and Arg, and can regulate F-actin structures within the cellular cytoskeleton. Actin polymerization plays a fundamental role in regulating T cell receptor-induced immunological synapse (IS) formation and chemokine-induced T cell migration. Conditional deletion of Abl-PTKs (Ts-DKO) in T lymphocytes reveals the role of Abl-PTKs in regulation of F-actin remodeling in IS formation and SDF-1alpha-induced T cell migration. Ts-DKO T cells exhibit excessive accumulation of F-actin at the IS, which is correlated with the modulation of the guanine nucleotide exchange factor (GEF) activity of Vav, since downregularion of Vav by Cbl requires phosphorylation by Abl-PTKs. In addition, we show that Ts-DKO T cells exhibit reduced T cell migration, actin reorganization and polarization in response to SDF-1alpha. Taken together, our results identify Abl-PTKs as key regulators of F-actin structures in IS and CXCR4 receptor-mediated T cell migration.

ISBN: 9780494526873Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration.
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020 $a 9780494526873
035 $a (UMI)AAIMR52687
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040 $a UMI $c UMI
100 1 $a Talaei, Nafiseh. $3 1682872
245 1 0 $a Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration.
300 $a 129 p.
500 $a Source: Masters Abstracts International, Volume: 48-02, page: 0984.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2009.
520 $a The Abelson family protein tyrosine kinases (Abl-PTKs) consist of c-Abl and Arg, and can regulate F-actin structures within the cellular cytoskeleton. Actin polymerization plays a fundamental role in regulating T cell receptor-induced immunological synapse (IS) formation and chemokine-induced T cell migration. Conditional deletion of Abl-PTKs (Ts-DKO) in T lymphocytes reveals the role of Abl-PTKs in regulation of F-actin remodeling in IS formation and SDF-1alpha-induced T cell migration. Ts-DKO T cells exhibit excessive accumulation of F-actin at the IS, which is correlated with the modulation of the guanine nucleotide exchange factor (GEF) activity of Vav, since downregularion of Vav by Cbl requires phosphorylation by Abl-PTKs. In addition, we show that Ts-DKO T cells exhibit reduced T cell migration, actin reorganization and polarization in response to SDF-1alpha. Taken together, our results identify Abl-PTKs as key regulators of F-actin structures in IS and CXCR4 receptor-mediated T cell migration.
590 $a School code: 0779.
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0982
710 2 $a University of Toronto (Canada). $3 1017674
773 0 $t Masters Abstracts International $g 48-02.
790 $a 0779
791 $a M.Sc.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR52687