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Methionine sulfoxide reductase in ne...

Oien, Derek B.

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Methionine sulfoxide reductase in neurodegenerative disease and locomotor-associated dopamine signaling.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Methionine sulfoxide reductase in neurodegenerative disease and locomotor-associated dopamine signaling./
Author:	Oien, Derek B.
Description:	234 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 3039.
Contained By:	Dissertation Abstracts International71-05B.
Subject:	Biology, Neurobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3398832
ISBN:	9781109727203

Methionine sulfoxide reductase in neurodegenerative disease and locomotor-associated dopamine signaling.
Oien, Derek B.

Methionine sulfoxide reductase in neurodegenerative disease and locomotor-associated dopamine signaling. - 234 p.

Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 3039.

Thesis (Ph.D.)--University of Kansas, 2010.

Reactive oxygen species can cause posttranslational modifications to amino acids, including sulfur-containing methionine. Methionine sulfoxide modifications are reduced by methionine sulfoxide reductase enzymes. The redox balance between reactive oxygen species and the methionine sulfoxide reductase system is disrupted in the aging process. This loss of antioxidant homeostasis can result in disease, and neurons may be particularly susceptible to the impact of methionine sulfoxide in proteins. Here we present evidence for the disruption of cell signaling processes in neuronal protein metabolism, and neurodegeneration in organisms lacking the methionine sulfoxide reductase A gene. In addition, we present data supporting the novel concept of the compromising effect of methionine oxidation on dopaminergic receptor function that is linked to movement regulation. Consequently, it is predicted that enhancing the activity of the methionine sulfoxide reductase system may be beneficial in preventing oxidative stress-related changes in brain function and neurodegenerative diseases.

ISBN: 9781109727203Subjects--Topical Terms:

1681328
Biology, Neurobiology.

Methionine sulfoxide reductase in neurodegenerative disease and locomotor-associated dopamine signaling.
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020 $a 9781109727203
035 $a (UMI)AAI3398832
035 $a AAI3398832
040 $a UMI $c UMI
100 1 $a Oien, Derek B. $3 1682790
245 1 0 $a Methionine sulfoxide reductase in neurodegenerative disease and locomotor-associated dopamine signaling.
300 $a 234 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 3039.
500 $a Adviser: Jackob Moskovitz.
502 $a Thesis (Ph.D.)--University of Kansas, 2010.
520 $a Reactive oxygen species can cause posttranslational modifications to amino acids, including sulfur-containing methionine. Methionine sulfoxide modifications are reduced by methionine sulfoxide reductase enzymes. The redox balance between reactive oxygen species and the methionine sulfoxide reductase system is disrupted in the aging process. This loss of antioxidant homeostasis can result in disease, and neurons may be particularly susceptible to the impact of methionine sulfoxide in proteins. Here we present evidence for the disruption of cell signaling processes in neuronal protein metabolism, and neurodegeneration in organisms lacking the methionine sulfoxide reductase A gene. In addition, we present data supporting the novel concept of the compromising effect of methionine oxidation on dopaminergic receptor function that is linked to movement regulation. Consequently, it is predicted that enhancing the activity of the methionine sulfoxide reductase system may be beneficial in preventing oxidative stress-related changes in brain function and neurodegenerative diseases.
590 $a School code: 0099.
650 4 $a Biology, Neurobiology. $3 1681328
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Aging. $3 1669845
690 $a 0421
690 $a 0487
690 $a 0493
710 2 $a University of Kansas. $b Pharmacology & Toxicology. $3 1023919
773 0 $t Dissertation Abstracts International $g 71-05B.
790 1 0 $a Moskovitz, Jackob, $e advisor
790 1 0 $a Fowler, Stephen C. $e committee member
790 1 0 $a Michaelis, Mary L. $e committee member
790 1 0 $a Shi, Honglian $e committee member
790 1 0 $a Johnson, Michael A. $e committee member
790 $a 0099
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3398832