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A search for longevity genes in Caen...

Judy, Meredith.

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A search for longevity genes in Caenorhabditis elegans identifies a MARVEL domain-containing protein regulating innate immunity and lifespan.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	A search for longevity genes in Caenorhabditis elegans identifies a MARVEL domain-containing protein regulating innate immunity and lifespan./
Author:	Judy, Meredith.
Description:	198 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0838.
Contained By:	Dissertation Abstracts International71-02B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3390109
ISBN:	9781109580754

A search for longevity genes in Caenorhabditis elegans identifies a MARVEL domain-containing protein regulating innate immunity and lifespan.
Judy, Meredith.

A search for longevity genes in Caenorhabditis elegans identifies a MARVEL domain-containing protein regulating innate immunity and lifespan. - 198 p.

Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0838.

Thesis (Ph.D.)--University of California, San Francisco, 2009.

To date, many genes and pathways regulating lifespan have been identified in the nematode Caenorhabditis elegans. Over 20 years of research have uncovered conserved roles for insulin signaling, metabolism, dietary restriction, and reproductive signaling in the control of lifespan. Yet, despite this work, we still lack a complete picture of aging. To identify new components of lifespan regulation, we undertook two RNAi-based screens. In the first, we searched for genes which, when knocked down, accelerate aging in C. elegans. Using lifespan analysis as well as analysis of tissue morphology, we identified five potential "progeria regulators". These five genes, four of which were independently identified by other researchers, negatively regulate lifespan. Further work will determine their exact role in aging regulation.

ISBN: 9781109580754Subjects--Topical Terms:

1017680
Biology, Neuroscience.

A search for longevity genes in Caenorhabditis elegans identifies a MARVEL domain-containing protein regulating innate immunity and lifespan.
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035 $a (UMI)AAI3390109
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100 1 $a Judy, Meredith. $3 1682762
245 1 2 $a A search for longevity genes in Caenorhabditis elegans identifies a MARVEL domain-containing protein regulating innate immunity and lifespan.
300 $a 198 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0838.
500 $a Adviser: Cynthia Kenyon.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2009.
520 $a To date, many genes and pathways regulating lifespan have been identified in the nematode Caenorhabditis elegans. Over 20 years of research have uncovered conserved roles for insulin signaling, metabolism, dietary restriction, and reproductive signaling in the control of lifespan. Yet, despite this work, we still lack a complete picture of aging. To identify new components of lifespan regulation, we undertook two RNAi-based screens. In the first, we searched for genes which, when knocked down, accelerate aging in C. elegans. Using lifespan analysis as well as analysis of tissue morphology, we identified five potential "progeria regulators". These five genes, four of which were independently identified by other researchers, negatively regulate lifespan. Further work will determine their exact role in aging regulation.
520 $a A separate RNAi screen for components of dietary restriction-mediated longevity also identified a negative regulator of lifespan. mrvl-1 encodes a MARVEL-domain containing membrane protein which is partially localized to the Golgi apparatus. RNAi inhibition of mrvl-1 significantly shortens lifespan and accelerates aging while overexpression extends lifespan in C. elegans. Using transcriptional profiling to identify genes involved in mrvl-1-regulation of aging, we found significant overlap with the lifespan-regulating daf-2/insulin/IGF-1 signaling pathway as well as with the innate immune response in C. elegans. Investigations into the immune activity of mrvl-1 revealed that whereas RNAi treatment causes increased sensitivity to the bacterial pathogen Pseudomonas aeruginosa, overexpression of mrvl-1 increases resistance. As bacterial food sources may potentially pose a late-life hazard to C. elegans, mrvl-1 likely helps the worm cope with the detrimental effects of proliferating and pathogenic bacteria. Indeed, mrvl-1 overexpression no longer extends the lifespan of animals fed nonproliferating, UV-killed bacteria. This work describes a novel lifespan gene that protects the worm from harmful bacteria, thus promoting survival and extending lifespan.
590 $a School code: 0034.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Aging. $3 1669845
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710 2 $a University of California, San Francisco. $b Neuroscience. $3 1267784
773 0 $t Dissertation Abstracts International $g 71-02B.
790 1 0 $a Kenyon, Cynthia, $e advisor
790 1 0 $a Ashrafi, Kaveh $e committee member
790 1 0 $a McIntire, Steve $e committee member
790 1 0 $a Heberlein, Ulrike $e committee member
790 1 0 $a Kapahi, Pankaj $e committee member
790 $a 0034
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3390109