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Mechanisms of anti-proliferative eff...

Zimmermann, Maria Carla.

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Mechanisms of anti-proliferative effects of glyceollins in estrogen-dependent and -independent tumor cells.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Mechanisms of anti-proliferative effects of glyceollins in estrogen-dependent and -independent tumor cells./
作者:	Zimmermann, Maria Carla.
面頁冊數:	153 p.
附註:	Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3536.
Contained By:	Dissertation Abstracts International69-06B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3319375
ISBN:	9780549705871

Mechanisms of anti-proliferative effects of glyceollins in estrogen-dependent and -independent tumor cells.
Zimmermann, Maria Carla.

Mechanisms of anti-proliferative effects of glyceollins in estrogen-dependent and -independent tumor cells. - 153 p.

Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3536.

Thesis (Ph.D.)--Tulane University, 2008.

Glyceollin, a phytoestrogen isolated from soy, has recently been demonstrated to be an anti-estrogen with respect to estrogen receptor (ER), and an inhibitor of 17beta-estradiol-induced tumor progression. This novel project will be focused on the mechanisms of action of the phytoalexin glyceollin I.

ISBN: 9780549705871Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Mechanisms of anti-proliferative effects of glyceollins in estrogen-dependent and -independent tumor cells.
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245 1 0 $a Mechanisms of anti-proliferative effects of glyceollins in estrogen-dependent and -independent tumor cells.
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500 $a Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3536.
500 $a Adviser: Barbara S. Beckman.
502 $a Thesis (Ph.D.)--Tulane University, 2008.
520 $a Glyceollin, a phytoestrogen isolated from soy, has recently been demonstrated to be an anti-estrogen with respect to estrogen receptor (ER), and an inhibitor of 17beta-estradiol-induced tumor progression. This novel project will be focused on the mechanisms of action of the phytoalexin glyceollin I.
520 $a Here, we investigated for the first time the antiestrogenic activities of glyceollin isomers (I, II and III) in a competition binding assay with human estrogen receptor alpha (hrER-alpha) and in an estrogen response element luciferase assay (ERE-Luc). We were able to identify the isomer glyceollin I as the active component of the mix. We also report studies evaluating the effects of glyceollin I in comparison to 4-hydroxy-tamoxifen (4-OH-Tam), ICI 182,780, and 17beta-estradiol (E2) in MCF-7 breast cancer cells and BG-1 ovarian cancer cells on the expression patterns of two genes: progesterone receptor (PgR) and stromal derived factor-1alpha (SDF-1alpha). In addition, the influence of this compound on cell proliferation and viability utilizing a well established clonogenic assay method was assessed. Furthermore, inhibition of proliferation on MDA-MB 231 ER-negative breast cancer cells was demonstrated. Taken together, our results support the hypothesis of a novel in vitro inhibition of estrogen-dependent and estrogen-independent cell proliferation. Although further studies will be needed, glyceollin I may represent an important component of a soy-based diet in terms of chemoprevention and treatment of estrogen-related cancer.
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790 1 0 $a Mondal, Debasis $e committee member
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