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Effects of membrane lateral organiza...

Zhu, Weiwei.

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Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells./
作者:	Zhu, Weiwei.
面頁冊數:	88 p.
附註:	Source: Masters Abstracts International, Volume: 48-06, page: 3680.
Contained By:	Masters Abstracts International48-06.
標題:	Chemistry, Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1479041
ISBN:	9781124105048

Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells.
Zhu, Weiwei.

Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells. - 88 p.

Source: Masters Abstracts International, Volume: 48-06, page: 3680.

Thesis (M.S.)--Temple University, 2010.

The goal of this research is to study how the cholesterol content in liposomal formulations affects the anticancer activity (e.g., cell growth suppression) of combretastatin A4 phosphate (CA4P). CA4P is a powerful antivascular agent currently under clinical trials for treating solid tumors. Liposomal CA4P has several advantages over free CA4P, including the reduced toxicities and the increased overall drug efficacy. In this thesis work, I have demonstrated that the proliferation of breast cancer MCF-7 cells varies with the cholesterol mole fraction in the formulation of liposomal CA4P in a biphasic manner, displaying a local minimum at the critical sterol mole fractions (Cr) for maximal superlattice formation. Cell proliferation was monitored using a fluorescence-based assay. Since cholesterol content determines membrane lateral organization, my results imply that membrane lateral organization plays an important role in regulating the anti-cancer activity of liposomal CA4P. This finding provides a new concept in the rational design of liposomal anti-cancer drugs. More than 20 anticancer drug formulations are in the market or under clinical trials. Most of them include cholesterol as a major component. My present study indicates that cholesterol is not just serving as a vesicle stabilizing agent, but also modulates the activity of liposomal drugs. The principle learned from CA4P can be extended to other liposomal anti-cancer drugs. This study is also significant from the membrane biophysics point of view. The data provide additional support for the sterol superlattice model and illustrate that the concept of sterol superlattice can be applied to biotechnology development.

ISBN: 9781124105048Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells.
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