東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Chromosomal interactions and its imp...

Lum, Thomas.

Linked to FindBook

Google Book

Amazon

博客來

Chromosomal interactions and its impact on gene regulation: Transvection at the Men locus in Drosophila melanogaster.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Chromosomal interactions and its impact on gene regulation: Transvection at the Men locus in Drosophila melanogaster./
Author:	Lum, Thomas.
Description:	85 p.
Notes:	Source: Masters Abstracts International, Volume: 49-04, page: 2336.
Contained By:	Masters Abstracts International49-04.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR71882
ISBN:	9780494718827

Chromosomal interactions and its impact on gene regulation: Transvection at the Men locus in Drosophila melanogaster.
Lum, Thomas.

Chromosomal interactions and its impact on gene regulation: Transvection at the Men locus in Drosophila melanogaster. - 85 p.

Source: Masters Abstracts International, Volume: 49-04, page: 2336.

Thesis (M.Sc.)--Laurentian University (Canada), 2011.

Gene regulation can be a complex process in which many cis- and trans-interactions determine the final pattern of expression: Among these interactions are trans-interactions mediated by the pairing of homologous chromosomes. Here I discuss transvection, the modulation of gene expression mediated by trans-interactions that are dependent on the pairing of homologous chromosomes, in three separate chapters. Chapter I reviews previous published studies of transvection, including molecular mechanisms to which transvection can occur. Chapter 2 discusses my study of transvection at the Malic enzyme locus. Chapter 3 describes future studies for transvection at the Malic enzyme locus. My study describes a novel case of transvection at the Malic enzyme (Men) locus. Using both empirical biochemical and predictive bioinformatic approaches, I show that the removal of putative regulatory elements on a non-functional allele is capable of interacting in trans, and can alter Men gene expression on a functional allele in heterozygotes. Furthermore, I show that non-local factors -- different genetic backgrounds -- are capable of significant interactions with individual Men alleles, suggesting that the trans effect that was documented is modified by both locally and distantly acting elements. In sum, my results emphasize the complexity of gene regulation and the need to understand both small- and large-scale interactions as more complete models of gene regulation and the role of trans-interactions are developed.

ISBN: 9780494718827Subjects--Topical Terms:

1017719
Biology, Molecular.

Chromosomal interactions and its impact on gene regulation: Transvection at the Men locus in Drosophila melanogaster.
LDR:02369nam 2200265 4500 001 1403102
005 20111108080421.5
008 130515s2011 ||||||||||||||||| ||eng d
020 $a 9780494718827
035 $a (UMI)AAIMR71882
035 $a AAIMR71882
040 $a UMI $c UMI
100 1 $a Lum, Thomas. $3 1682345
245 1 0 $a Chromosomal interactions and its impact on gene regulation: Transvection at the Men locus in Drosophila melanogaster.
300 $a 85 p.
500 $a Source: Masters Abstracts International, Volume: 49-04, page: 2336.
502 $a Thesis (M.Sc.)--Laurentian University (Canada), 2011.
520 $a Gene regulation can be a complex process in which many cis- and trans-interactions determine the final pattern of expression: Among these interactions are trans-interactions mediated by the pairing of homologous chromosomes. Here I discuss transvection, the modulation of gene expression mediated by trans-interactions that are dependent on the pairing of homologous chromosomes, in three separate chapters. Chapter I reviews previous published studies of transvection, including molecular mechanisms to which transvection can occur. Chapter 2 discusses my study of transvection at the Malic enzyme locus. Chapter 3 describes future studies for transvection at the Malic enzyme locus. My study describes a novel case of transvection at the Malic enzyme (Men) locus. Using both empirical biochemical and predictive bioinformatic approaches, I show that the removal of putative regulatory elements on a non-functional allele is capable of interacting in trans, and can alter Men gene expression on a functional allele in heterozygotes. Furthermore, I show that non-local factors -- different genetic backgrounds -- are capable of significant interactions with individual Men alleles, suggesting that the trans effect that was documented is modified by both locally and distantly acting elements. In sum, my results emphasize the complexity of gene regulation and the need to understand both small- and large-scale interactions as more complete models of gene regulation and the role of trans-interactions are developed.
590 $a School code: 1100.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Bioinformatics. $3 1018415
690 $a 0307
690 $a 0369
690 $a 0715
710 2 $a Laurentian University (Canada). $3 1019463
773 0 $t Masters Abstracts International $g 49-04.
790 $a 1100
791 $a M.Sc.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR71882