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Computational Modeling of Anti-aggre...

Chang, Wenling E.

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Computational Modeling of Anti-aggregation Effect of Non-steroidal Anti-inflammatory Drugs in Alzheimer's Amyloidogenesis.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Computational Modeling of Anti-aggregation Effect of Non-steroidal Anti-inflammatory Drugs in Alzheimer's Amyloidogenesis./
作者:	Chang, Wenling E.
面頁冊數:	73 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
Contained By:	Dissertation Abstracts International72-07B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3455326
ISBN:	9781124629629

Computational Modeling of Anti-aggregation Effect of Non-steroidal Anti-inflammatory Drugs in Alzheimer's Amyloidogenesis.
Chang, Wenling E.

Computational Modeling of Anti-aggregation Effect of Non-steroidal Anti-inflammatory Drugs in Alzheimer's Amyloidogenesis. - 73 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--George Mason University, 2011.

Alzheimer's disease (AD) represents a growing biomedical, social, and economical problem. Millions of people have suffered from the disease globally. Studies have shown that aggregated forms of amyloid beta peptide adversely affect neuronal function and may represent the causative agent in AD. It has been demonstrated that chronic treatment with ibuprofen and naproxen reduces the risk of AD and improves the behavioral impairment for patients with AD. This dissertation utilizes high performance parallel computing, all-atom molecular dynamics simulation, and protein-ligand docking to understand the mechanism of the anti-aggregation effect of ibuprofen and naproxen in Alzheimer's amyloidogenesis. The results reveal different mechanisms of ligand binding to the monomers and fibrils formed by Abeta peptides implicated in AD. Binding to Abeta monomers is mostly governed by ligand-amino acid interactions, whereas binding to the fibril is determined by the fibril surface geometry and interligand interactions. The anti-aggregation effect of ibuprofen and naproxen is explained by direct competition between these ligands and incoming Abeta peptides for binding to the fibril.

ISBN: 9781124629629Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Computational Modeling of Anti-aggregation Effect of Non-steroidal Anti-inflammatory Drugs in Alzheimer's Amyloidogenesis.
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