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Statistical methods in genetic assoc...

Xiao, Rui.

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Statistical methods in genetic association studies.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Statistical methods in genetic association studies./
Author:	Xiao, Rui.
Description:	101 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 2763.
Contained By:	Dissertation Abstracts International71-05B.
Subject:	Biology, Biostatistics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3406242
ISBN:	9781109729634

Statistical methods in genetic association studies.
Xiao, Rui.

Statistical methods in genetic association studies. - 101 p.

Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 2763.

Thesis (Ph.D.)--University of Michigan, 2010.

For the past a few years, the genomewide association studies (GWAS) have rapidly grown in scale and complexity, and have provided new insights into complex disease genetics. For loci identified by GWAS, investigators are often interested in estimating the genetic effect size to help understand the genetic contribution of these loci to the disease risk or trait variation. However, estimates of the genetic effect size based on initial GWAS sample(s) tend to be upwardly biased as a consequence of "winner's curse". Overestimation of genetic effect size in initial studies may cause follow-up studies to be underpowered and so to fail.

ISBN: 9781109729634Subjects--Topical Terms:

1018416
Biology, Biostatistics.

Statistical methods in genetic association studies.
LDR:03041nam 2200301 4500 001 1402992
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020 $a 9781109729634
035 $a (UMI)AAI3406242
035 $a AAI3406242
040 $a UMI $c UMI
100 1 $a Xiao, Rui. $3 1682223
245 1 0 $a Statistical methods in genetic association studies.
300 $a 101 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-05, Section: B, page: 2763.
500 $a Adviser: Michael L. Boehnke.
502 $a Thesis (Ph.D.)--University of Michigan, 2010.
520 $a For the past a few years, the genomewide association studies (GWAS) have rapidly grown in scale and complexity, and have provided new insights into complex disease genetics. For loci identified by GWAS, investigators are often interested in estimating the genetic effect size to help understand the genetic contribution of these loci to the disease risk or trait variation. However, estimates of the genetic effect size based on initial GWAS sample(s) tend to be upwardly biased as a consequence of "winner's curse". Overestimation of genetic effect size in initial studies may cause follow-up studies to be underpowered and so to fail.
520 $a In Chapter 2 of this dissertation, I quantify the impact of the winner's curse for one- and two-stage case-control association studies. I then propose an ascertainment-corrected maximum likelihood method to reduce the bias and so achieve more accurate estimation of genetic effect size. I show that overestimation of the genetic effect by the uncorrected estimator decreases as the power of the association study increases and that the ascertainment-corrected method reduces bias when power to detect association is low to moderate as expected for GWAS for complex disease. In Chapter 3, I extend this study to quantitative trait association studies and show that the results are similar to case-control association studies.
520 $a Following GWAS, testing for association between gene expression and identified SNPs has the potential to help understand the relationship between these SNPs with the trait, and identify the gene(s) and variants most likely to influence the trait. In Chapter 4, I describe five testing procedures for using the allelic expression imbalance (AEI) to detect cis-acting regulatory SNPs (rSNP), focusing on the situation when the rSNP and a transcribed SNP (tSNP) are in incomplete linkage disequilibrium (LD) and there is no phase information. My simulations show that the type I error rates for all tests are well controlled, and the relative rankings of the tests depend on the LD between the two SNPs, AEI effect size of the rSNP, sample size, and allele frequencies of the SNPs.
590 $a School code: 0127.
650 4 $a Biology, Biostatistics. $3 1018416
650 4 $a Biology, Genetics. $3 1017730
690 $a 0308
690 $a 0369
710 2 $a University of Michigan. $3 777416
773 0 $t Dissertation Abstracts International $g 71-05B.
790 1 0 $a Boehnke, Michael L., $e advisor
790 $a 0127
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3406242