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Cancer Drug Delivery: The Role of Ex...

Diop-Frimpong, Benjamin.

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Cancer Drug Delivery: The Role of Extracellular Matrix Structure.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Cancer Drug Delivery: The Role of Extracellular Matrix Structure./
Author:	Diop-Frimpong, Benjamin.
Description:	168 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: .
Contained By:	Dissertation Abstracts International72-04B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3446137
ISBN:	9781124500386

Cancer Drug Delivery: The Role of Extracellular Matrix Structure.
Diop-Frimpong, Benjamin.

Cancer Drug Delivery: The Role of Extracellular Matrix Structure. - 168 p.

Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: .

Thesis (Ph.D.)--Harvard University, 2011.

Recent studies have shown that the inefficiency of nanotherapeutics in tumors can be attributed, in part, to transport hindrance posed by the vasculature, and components of the tumor interstitium. Although several agents have been used to improve the distribution and efficacy of nanotherapeutics in tumors, many of these agents have shown negative effects on tumor growth and progression. Furthermore, the exact role of the structure and organization of interstitial components like collagen on drug distribution and efficacy is not clearly known.

ISBN: 9781124500386Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Cancer Drug Delivery: The Role of Extracellular Matrix Structure.
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020 $a 9781124500386
035 $a (UMI)AAI3446137
035 $a AAI3446137
040 $a UMI $c UMI
100 1 $a Diop-Frimpong, Benjamin. $3 1681340
245 1 0 $a Cancer Drug Delivery: The Role of Extracellular Matrix Structure.
300 $a 168 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: .
500 $a Adviser: Rakesh Jain.
502 $a Thesis (Ph.D.)--Harvard University, 2011.
520 $a Recent studies have shown that the inefficiency of nanotherapeutics in tumors can be attributed, in part, to transport hindrance posed by the vasculature, and components of the tumor interstitium. Although several agents have been used to improve the distribution and efficacy of nanotherapeutics in tumors, many of these agents have shown negative effects on tumor growth and progression. Furthermore, the exact role of the structure and organization of interstitial components like collagen on drug distribution and efficacy is not clearly known.
520 $a The goal of this thesis is to determine the effect of collagen I structure on interstitial transport and develop a clinically translatable and safe method of increasing diffusion in the tumor interstitium by modifying the structure and organization of collagen fibers. To accomplish this goal, we tested three major hypotheses. We first tested whether the transport of nanoparticles in collagen hydrogels and tumors is affected by the structure and organization of collagen fibers. Then we determined whether nanoparticle transport in tumors could be improved by modifying the interstitial collagen matrix organization and structure. Finally, we tested whether the efficacy of nanotherapeutic agents can be improved in tumors by modifying the interstitial matrix structure with a collagen modifying pharmaceutical agent.
520 $a Our findings show that modifying the structure of in vitro and in vivo collagen I networks improves nanoparticle transport and distribution. We also show that the antitumor efficacy of oncolytic HSV and liposomal doxorubicin with a clinically approved agent that modifies collagen matrices in tumors.
590 $a School code: 0084.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Biophysics, General. $3 1019105
690 $a 0541
690 $a 0542
690 $a 0786
710 2 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 72-04B.
790 1 0 $a Jain, Rakesh, $e advisor
790 $a 0084
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3446137