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Identification and characterization ...

Gu, Yiben.

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Identification and characterization of Her2/Neu-transformed breast cancer stem cells.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Identification and characterization of Her2/Neu-transformed breast cancer stem cells./
Author:	Gu, Yiben.
Description:	60 p.
Notes:	Source: Masters Abstracts International, Volume: 49-01, page: 0258.
Contained By:	Masters Abstracts International49-01.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1479443
ISBN:	9781124135687

Identification and characterization of Her2/Neu-transformed breast cancer stem cells.
Gu, Yiben.

Identification and characterization of Her2/Neu-transformed breast cancer stem cells. - 60 p.

Source: Masters Abstracts International, Volume: 49-01, page: 0258.

Thesis (M.S.)--University of South Carolina, 2010.

A variety of human solid tumors, including breast cancer, are considered to embrace a hierarchical organization in which only infrequent tumor-initiating cancer stem cells are truly responsible for tumor formation rather than the non-tumorigenic majority. However, these cancer stem cells remain elusive and vaguely characterized due to the absence of suitable cultivation systems and lack of specific markers. To study breast cancer stem cells in our model system that mimics Her2-positive subtype of human breast cancer, we cultivated primary tumor cells and grew tumorspheres under non-adherent condition. Cells capable of forming tumorspheres retained ability of self-renewal and capacity for initiating tumors that recapitulate the original heterogeneity, which resembled normal stem cells within normal tissues. We also investigated how the cancer stem cell fate was determined by the extracellular matrix (collagen, fibronectin and laminin), and found that cell differentiation was induced, resulting in attenuated tumorigenic potential.

ISBN: 9781124135687Subjects--Topical Terms:

1017719
Biology, Molecular.

Identification and characterization of Her2/Neu-transformed breast cancer stem cells.
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100 1 $a Gu, Yiben. $3 1680678
245 1 0 $a Identification and characterization of Her2/Neu-transformed breast cancer stem cells.
300 $a 60 p.
500 $a Source: Masters Abstracts International, Volume: 49-01, page: 0258.
500 $a Adviser: Hexin Chen.
502 $a Thesis (M.S.)--University of South Carolina, 2010.
520 $a A variety of human solid tumors, including breast cancer, are considered to embrace a hierarchical organization in which only infrequent tumor-initiating cancer stem cells are truly responsible for tumor formation rather than the non-tumorigenic majority. However, these cancer stem cells remain elusive and vaguely characterized due to the absence of suitable cultivation systems and lack of specific markers. To study breast cancer stem cells in our model system that mimics Her2-positive subtype of human breast cancer, we cultivated primary tumor cells and grew tumorspheres under non-adherent condition. Cells capable of forming tumorspheres retained ability of self-renewal and capacity for initiating tumors that recapitulate the original heterogeneity, which resembled normal stem cells within normal tissues. We also investigated how the cancer stem cell fate was determined by the extracellular matrix (collagen, fibronectin and laminin), and found that cell differentiation was induced, resulting in attenuated tumorigenic potential.
590 $a School code: 0202.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Oncology. $3 1018566
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710 2 $a University of South Carolina. $b Biological Sciences. $3 1677682
773 0 $t Masters Abstracts International $g 49-01.
790 1 0 $a Chen, Hexin, $e advisor
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790 1 0 $a AI, WALDEN $e committee member
790 $a 0202
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1479443