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MAP kinase phosphorylation is dispen...

Majumdar, Neena.

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MAP kinase phosphorylation is dispensable for cell division, but not for cell growth in Drosophila.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	MAP kinase phosphorylation is dispensable for cell division, but not for cell growth in Drosophila./
Author:	Majumdar, Neena.
Description:	35 p.
Notes:	Source: Masters Abstracts International, Volume: 48-02, page: 0882.
Contained By:	Masters Abstracts International48-02.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1472645
ISBN:	9781109499063

MAP kinase phosphorylation is dispensable for cell division, but not for cell growth in Drosophila.
Majumdar, Neena.

MAP kinase phosphorylation is dispensable for cell division, but not for cell growth in Drosophila. - 35 p.

Source: Masters Abstracts International, Volume: 48-02, page: 0882.

Thesis (M.S.)--University of the Sciences in Philadelphia, 2010.

Regulation of the Ras/MAPK pathway is integral for cell fate and function. A cell can regulate this pathway in a number of ways: through changes in the levels of positive ligands, addition of inhibitors, temporal regulation of activation, and localization of the downstream effectors in the cell (to name a few). We report here for the first time another mode of regulation of the Ras/MAPK pathway through phosphorylation of Ras/MAPK effectors in Drosophila melanogaster. Phosphorylated MAPK (pMAPK) is a key protein activated downstream of Ras, and regulates cell division and differentiation depending on whether it is localized in the nucleus or cytoplasm respectively. This study shows that inhibition of phosphorylation of MAPK in both wings and eyes affects differentiation and cell growth but does not affect division Inhibition of the Ras/MAPK is used as a mechanism for controlling tumor growth by many cancer drugs. Taken together, the results might be an answer to the variability in the efficacy of a cancer drug in many tumor types.

ISBN: 9781109499063Subjects--Topical Terms:

1017730
Biology, Genetics.

MAP kinase phosphorylation is dispensable for cell division, but not for cell growth in Drosophila.
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100 1 $a Majumdar, Neena. $3 1680671
245 1 0 $a MAP kinase phosphorylation is dispensable for cell division, but not for cell growth in Drosophila.
300 $a 35 p.
500 $a Source: Masters Abstracts International, Volume: 48-02, page: 0882.
500 $a Adviser: Daniel Marenda.
502 $a Thesis (M.S.)--University of the Sciences in Philadelphia, 2010.
520 $a Regulation of the Ras/MAPK pathway is integral for cell fate and function. A cell can regulate this pathway in a number of ways: through changes in the levels of positive ligands, addition of inhibitors, temporal regulation of activation, and localization of the downstream effectors in the cell (to name a few). We report here for the first time another mode of regulation of the Ras/MAPK pathway through phosphorylation of Ras/MAPK effectors in Drosophila melanogaster. Phosphorylated MAPK (pMAPK) is a key protein activated downstream of Ras, and regulates cell division and differentiation depending on whether it is localized in the nucleus or cytoplasm respectively. This study shows that inhibition of phosphorylation of MAPK in both wings and eyes affects differentiation and cell growth but does not affect division Inhibition of the Ras/MAPK is used as a mechanism for controlling tumor growth by many cancer drugs. Taken together, the results might be an answer to the variability in the efficacy of a cancer drug in many tumor types.
590 $a School code: 1379.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Cell. $3 1017686
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710 2 $a University of the Sciences in Philadelphia. $3 1017850
773 0 $t Masters Abstracts International $g 48-02.
790 1 0 $a Marenda, Daniel, $e advisor
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792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1472645