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HIV initiates multiple signaling cas...

Kelly, Jeremy.

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HIV initiates multiple signaling cascades required for effective replication.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	HIV initiates multiple signaling cascades required for effective replication./
Author:	Kelly, Jeremy.
Description:	144 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2237.
Contained By:	Dissertation Abstracts International71-04B.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3405157
ISBN:	9781109707533

HIV initiates multiple signaling cascades required for effective replication.
Kelly, Jeremy.

HIV initiates multiple signaling cascades required for effective replication. - 144 p.

Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2237.

Thesis (Ph.D.)--George Mason University, 2010.

The Human Immunodeficiency Virus (HIV) infects lymphocytes by binding to CD4 and either the CXCR4 or CCR5 receptor. Signaling initiated by these receptors in response to the virus was found to be unnecessary for viral infection. Recent work by the Wu lab has demonstrated that in resting CD4 T cells CXCR4 signaling is necessary to overcome cortical actin restriction. Here we show that multiple signaling cascades are not only initiated by HIV and CD4/CXCR4 signaling, but that this signaling can impact viral replication in non-resting cells. We specifically identify the JAK/STAT pathway as a necessary component of early viral transcription; which has implications for not only novel therapeutics but also for understanding how we view viral interactions with the immune system.

ISBN: 9781109707533Subjects--Topical Terms:

1017719
Biology, Molecular.

HIV initiates multiple signaling cascades required for effective replication.
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100 1 $a Kelly, Jeremy. $3 1680542
245 1 0 $a HIV initiates multiple signaling cascades required for effective replication.
300 $a 144 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2237.
500 $a Adviser: Yuntao Wu.
502 $a Thesis (Ph.D.)--George Mason University, 2010.
520 $a The Human Immunodeficiency Virus (HIV) infects lymphocytes by binding to CD4 and either the CXCR4 or CCR5 receptor. Signaling initiated by these receptors in response to the virus was found to be unnecessary for viral infection. Recent work by the Wu lab has demonstrated that in resting CD4 T cells CXCR4 signaling is necessary to overcome cortical actin restriction. Here we show that multiple signaling cascades are not only initiated by HIV and CD4/CXCR4 signaling, but that this signaling can impact viral replication in non-resting cells. We specifically identify the JAK/STAT pathway as a necessary component of early viral transcription; which has implications for not only novel therapeutics but also for understanding how we view viral interactions with the immune system.
590 $a School code: 0883.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Virology. $3 1019068
690 $a 0307
690 $a 0369
690 $a 0720
710 2 $a George Mason University. $3 1019450
773 0 $t Dissertation Abstracts International $g 71-04B.
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790 $a 0883
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792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3405157