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An implantable biomedical device and...

Oni, Yusuf Olanrewaju.

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An implantable biomedical device and nanoparticles for cancer drug release and hyperthermia.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	An implantable biomedical device and nanoparticles for cancer drug release and hyperthermia./
Author:	Oni, Yusuf Olanrewaju.
Description:	188 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-11, Section: B, page: 6921.
Contained By:	Dissertation Abstracts International71-11B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3428537
ISBN:	9781124280417

An implantable biomedical device and nanoparticles for cancer drug release and hyperthermia.
Oni, Yusuf Olanrewaju.

An implantable biomedical device and nanoparticles for cancer drug release and hyperthermia. - 188 p.

Source: Dissertation Abstracts International, Volume: 71-11, Section: B, page: 6921.

Thesis (Ph.D.)--Princeton University, 2010.

The importance of implantable drug delivery devices cannot be over-emphasized. They allow for specific targeting through localized delivery coupled with reduced side effects. The current work introduces a multi-modal device that can potentially kill cancer cells by chemotherapy and hyperthermia with the advantage of combining these two therapeutic interventions into one device, over prior devices. This thesis therefore presents the recent results of a theoretical and experimental study of a novel implantable drug delivery system. The release from the device is controlled by the swelling and diffusion of poly(N-iso-propyl-acrylamide) PNIPA-based gels. The swelling due to the uptake of water, rhodamine dye and the cancer drug, paclitaxel(TM), are studied using weight gain experiments that are conducted over a range of temperatures in which hyperthermia (37-45°C) can occur during drug delivery to understand the underlying mechanisms of diffusion and swelling. Subsequently, the elutions of rhodamine dye and cancer drug, paclitaxel(TM) are studied within this temperature range, with the release shown to be well described by monolithic and membrane diffusion models. In-vitro studies are also carried out to explore the synergy that can occur at 43°C, where lesser amounts of drugs can be used to achieve therapeutic effects when drug delivery is combined with heat. Finally, this work reports the results of adhesion studies on nanoparticle clusters that can be used to provide cancer therapy by both drug delivery and localized heating. Atomic force microscopy was used to study the adhesion that can occur between the constituents of such systems. The implications of the results are discussed for the development of robust drug delivery devices and nanoparticle clusters that can treat cancer locally via the combined effects of chemotherapy and hyperthermia.

ISBN: 9781124280417Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

An implantable biomedical device and nanoparticles for cancer drug release and hyperthermia.
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245 1 3 $a An implantable biomedical device and nanoparticles for cancer drug release and hyperthermia.
300 $a 188 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-11, Section: B, page: 6921.
500 $a Adviser: Winston O. Soboyejo.
502 $a Thesis (Ph.D.)--Princeton University, 2010.
520 $a The importance of implantable drug delivery devices cannot be over-emphasized. They allow for specific targeting through localized delivery coupled with reduced side effects. The current work introduces a multi-modal device that can potentially kill cancer cells by chemotherapy and hyperthermia with the advantage of combining these two therapeutic interventions into one device, over prior devices. This thesis therefore presents the recent results of a theoretical and experimental study of a novel implantable drug delivery system. The release from the device is controlled by the swelling and diffusion of poly(N-iso-propyl-acrylamide) PNIPA-based gels. The swelling due to the uptake of water, rhodamine dye and the cancer drug, paclitaxel(TM), are studied using weight gain experiments that are conducted over a range of temperatures in which hyperthermia (37-45°C) can occur during drug delivery to understand the underlying mechanisms of diffusion and swelling. Subsequently, the elutions of rhodamine dye and cancer drug, paclitaxel(TM) are studied within this temperature range, with the release shown to be well described by monolithic and membrane diffusion models. In-vitro studies are also carried out to explore the synergy that can occur at 43°C, where lesser amounts of drugs can be used to achieve therapeutic effects when drug delivery is combined with heat. Finally, this work reports the results of adhesion studies on nanoparticle clusters that can be used to provide cancer therapy by both drug delivery and localized heating. Atomic force microscopy was used to study the adhesion that can occur between the constituents of such systems. The implications of the results are discussed for the development of robust drug delivery devices and nanoparticle clusters that can treat cancer locally via the combined effects of chemotherapy and hyperthermia.
590 $a School code: 0181.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
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773 0 $t Dissertation Abstracts International $g 71-11B.
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