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Harmony search optimization for HDR ...

Panchal, Aditya.

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Harmony search optimization for HDR prostate brachytherapy.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Harmony search optimization for HDR prostate brachytherapy./
Author:	Panchal, Aditya.
Description:	117 p.
Notes:	Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2391.
Contained By:	Dissertation Abstracts International69-04B.
Subject:	Health Sciences, Radiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3304316
ISBN:	9780549534365

Harmony search optimization for HDR prostate brachytherapy.
Panchal, Aditya.

Harmony search optimization for HDR prostate brachytherapy. - 117 p.

Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2391.

Thesis (Ph.D.)--Rosalind Franklin University of Medicine and Science, 2008.

In high dose-rate (HDR) prostate brachytherapy, multiple catheters are inserted interstitially into the target volume. The process of treating the prostate involves calculating and determining the best dose distribution to the target and organs-at-risk by means of optimizing the time that the radioactive source dwells at specified positions within the catheters. It is the goal of this work to investigate the use of a new optimization algorithm, known as Harmony Search, in order to optimize dwell times for HDR prostate brachytherapy. The new algorithm was tested on 9 different patients and also compared with the genetic algorithm. Simulations were performed to determine the optimal value of the Harmony Search parameters. Finally, multithreading of the simulation was examined to determine potential benefits.

ISBN: 9780549534365Subjects--Topical Terms:

1019076
Health Sciences, Radiology.

Harmony search optimization for HDR prostate brachytherapy.
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020 $a 9780549534365
035 $a (UMI)AAI3304316
035 $a AAI3304316
040 $a UMI $c UMI
100 1 $a Panchal, Aditya. $3 1676627
245 1 0 $a Harmony search optimization for HDR prostate brachytherapy.
300 $a 117 p.
500 $a Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2391.
500 $a Advisers: John H. LeVan; Brian C. Tom.
502 $a Thesis (Ph.D.)--Rosalind Franklin University of Medicine and Science, 2008.
520 $a In high dose-rate (HDR) prostate brachytherapy, multiple catheters are inserted interstitially into the target volume. The process of treating the prostate involves calculating and determining the best dose distribution to the target and organs-at-risk by means of optimizing the time that the radioactive source dwells at specified positions within the catheters. It is the goal of this work to investigate the use of a new optimization algorithm, known as Harmony Search, in order to optimize dwell times for HDR prostate brachytherapy. The new algorithm was tested on 9 different patients and also compared with the genetic algorithm. Simulations were performed to determine the optimal value of the Harmony Search parameters. Finally, multithreading of the simulation was examined to determine potential benefits.
520 $a First, a simulation environment was created using the Python programming language and the wxPython graphical interface toolkit, which was necessary to run repeated optimizations. DICOM RT data from Varian BrachyVision was parsed and used to obtain patient anatomy and HDR catheter information. Once the structures were indexed, the volume of each structure was determined and compared to the original volume calculated in BrachyVision for validation. Dose was calculated using the AAPM TG-43 point source model of the GammaMed 192Ir HDR source and was validated against Varian BrachyVision. A DVH-based objective function was created and used for the optimization simulation. Harmony Search and the genetic algorithm were implemented as optimization algorithms for the simulation and were compared against each other. The optimal values for Harmony Search parameters (Harmony Memory Size [HMS], Harmony Memory Considering Rate [HMCR], and Pitch Adjusting Rate [PAR]) were also determined. Lastly, the simulation was modified to use multiple threads of execution in order to achieve faster computational times.
520 $a Experimental results show that the volume calculation that was implemented in this thesis was within 2% of the values computed by Varian BrachyVision for the prostate, within 3% for the rectum and bladder and 6% for the urethra. The calculation of dose compared to BrachyVision was determined to be different by only 0.38%. Isodose curves were also generated and were found to be similar to BrachyVision. The comparison between Harmony Search and genetic algorithm showed that Harmony Search was over 4 times faster when compared over multiple data sets. The optimal Harmony Memory Size was found to be 5 or lower; the Harmony Memory Considering Rate was determined to be 0.95, and the Pitch Adjusting Rate was found to be 0.9. Ultimately, the effect of multithreading showed that as intensive computations such as optimization and dose calculation are involved, the threads of execution scale with the number of processors, achieving a speed increase proportional to the number of processor cores.
520 $a In conclusion, this work showed that Harmony Search is a viable alternative to existing algorithms for use in HDR prostate brachytherapy optimization. Coupled with the optimal parameters for the algorithm and a multithreaded simulation, this combination has the capability to significantly decrease the time spent on minimizing optimization problems in the clinic that are time intensive, such as brachytherapy, IMRT and beam angle optimization.
590 $a School code: 1489.
650 4 $a Health Sciences, Radiology. $3 1019076
650 4 $a Physics, Radiation. $3 1019212
650 4 $a Computer Science. $3 626642
690 $a 0574
690 $a 0756
690 $a 0984
710 2 $a Rosalind Franklin University of Medicine and Science. $b Medical Radiation Physics. $3 1676628
773 0 $t Dissertation Abstracts International $g 69-04B.
790 1 0 $a LeVan, John H., $e advisor
790 1 0 $a Tom, Brian C., $e advisor
790 1 0 $a Han, Kyung S. $e committee member
790 1 0 $a Helenowski, Tomasz K. $e committee member
790 1 0 $a Hrejsa, Allen F. $e committee member
790 1 0 $a Mosnaim, Aron $e committee member
790 1 0 $a Sukowski, Ernest $e committee member
790 $a 1489
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3304316