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Selected medications, cardiometaboli...

Bosco, Jaclyn Lee Fong.

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Selected medications, cardiometabolic risk factors, and breast cancer risk.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Selected medications, cardiometabolic risk factors, and breast cancer risk./
作者:	Bosco, Jaclyn Lee Fong.
面頁冊數:	144 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: .
Contained By:	Dissertation Abstracts International72-04B.
標題:	Health Sciences, Public Health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3445685
ISBN:	9781124491356

Selected medications, cardiometabolic risk factors, and breast cancer risk.
Bosco, Jaclyn Lee Fong.

Selected medications, cardiometabolic risk factors, and breast cancer risk. - 144 p.

Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: .

Thesis (Ph.D.)--Boston University, 2011.

A variety of genetic, reproductive, and behavioral risk factors have been identified as important risk factors for breast cancer. Known risk factors account for only about half of breast cancer cases diagnosed, but many of the known breast cancer risk factors are difficult to change.

ISBN: 9781124491356Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

Selected medications, cardiometabolic risk factors, and breast cancer risk.
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245 1 0 $a Selected medications, cardiometabolic risk factors, and breast cancer risk.
300 $a 144 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: .
500 $a Adviser: Lynn Rosenberg.
502 $a Thesis (Ph.D.)--Boston University, 2011.
520 $a A variety of genetic, reproductive, and behavioral risk factors have been identified as important risk factors for breast cancer. Known risk factors account for only about half of breast cancer cases diagnosed, but many of the known breast cancer risk factors are difficult to change.
520 $a In study 1, we prospectively evaluated the associations between regular aspirin, non- aspirin NSAIDs, and acetaminophen with incident breast cancer in 53,151 women of the Black Women's Health Study (BWHS). We observed that longer duration (≥ 5 years) of current aspirin was associated with a decreased risk of breast cancer in African American women after adjusting for age, education, body mass index at age 18, vigorous activity, female hormone use, and smoking. Similar inverse associations with acetaminophen use were also observed. Although acetaminophen has been shown to have anti-inflammatory properties in laboratory studies, findings from epidemiologic studies do not support an association between acetaminophen and breast cancer. Therefore, our results may suggest the possibility that the association observed for aspirin may be due to behaviors that are associated with pain medication use.
520 $a In study 2, we examined the associations of abdominal obesity, type 2 diabetes, hypertension, and high cholesterol individually and in combination with breast cancer incidence using data from the BWHS (N=49,172). Individual and combinations of cardiometabolic factors were largely unassociated with breast cancer incidence. We found weak support, if any, for an association between these factors individually or of metabolic syndrome (any three or more cardiometabolic risk factors) with breast cancer in African American women.
520 $a In study 3, we evaluated the effect of metformin medication on the risk of incident breast cancer among peri- and postmenopausal women (N=4,323) using a population-based case-control design. Metformin users were less likely to be diagnosed with breast cancer than non-metformin users. Our results suggest that metformin may protect against breast cancer in type 2 diabetic peri- or postmenopausal women. The present studies indicate potential opportunities for reducing breast cancer incidence. The findings from the present dissertation contribute to the existing evidence for new hypotheses for the etiology and prevention of breast cancer.
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