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Tong, Fan.

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Investigation of mechanisms of action of monoterpenoid insecticides on insect gamma-aminobutyric acid receptors and nicotinic acetylcholine receptors.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Investigation of mechanisms of action of monoterpenoid insecticides on insect gamma-aminobutyric acid receptors and nicotinic acetylcholine receptors./
Author:	Tong, Fan.
Description:	111 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-03, Section: B, page: .
Contained By:	Dissertation Abstracts International72-03B.
Subject:	Biology, Entomology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3438739
ISBN:	9781124430331

Investigation of mechanisms of action of monoterpenoid insecticides on insect gamma-aminobutyric acid receptors and nicotinic acetylcholine receptors.
Tong, Fan.

Investigation of mechanisms of action of monoterpenoid insecticides on insect gamma-aminobutyric acid receptors and nicotinic acetylcholine receptors. - 111 p.

Source: Dissertation Abstracts International, Volume: 72-03, Section: B, page: .

Thesis (Ph.D.)--Iowa State University, 2010.

Monoterpenoids and their derivatives from plant essential oils show potential to be a good alternative to conventional insecticides due to their relatively high toxicity to insect pests, low toxicity to non-target organisms, and biodegradability in the environment. This dissertation has investigated the possible mechanisms of action of monoterpenoid insecticides in the insect nervous system, including an inhibitory neurotransmitter receptor, the GABA receptor, and an excitatory neurotransmitter, the nicotinic acetylcholine receptor (nAChR). By using radioligand binding assays, 36Cl- uptake assays, and quantitative structure-activity relationship assays, monoterpenoid insecticides were suggested to bind to these two receptors, and could interfere with the function of them in the nervous system, which might be the reason why these naturally occurring compounds have toxicity to insects. In the Chapter 2, carvacrol, pulegone, and thymol showed binding activities on insect GABA receptor, and inhibitory effects on the insect nervous system. In the Chapter 3, some structural and chemical properties of monoterpenoids, including Mulliken charges, log P values, and total energy levels, were indicated to be related to the binding between monoterpenoids and the insect GABA receptor. In the Chapter 4, a potent monoterpenoid insecticide, carvacrol, showed binding activity on insect nAChR at a new binding site. This dissertation will help us to understand the mechanism of action of monoterpenoid insecticides further, and is meaningful to discover and develop novel green insecticides.

ISBN: 9781124430331Subjects--Topical Terms:

1018619
Biology, Entomology.

Investigation of mechanisms of action of monoterpenoid insecticides on insect gamma-aminobutyric acid receptors and nicotinic acetylcholine receptors.
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100 1 $a Tong, Fan. $3 1675642
245 1 0 $a Investigation of mechanisms of action of monoterpenoid insecticides on insect gamma-aminobutyric acid receptors and nicotinic acetylcholine receptors.
300 $a 111 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-03, Section: B, page: .
500 $a Adviser: Joel R. Coats.
502 $a Thesis (Ph.D.)--Iowa State University, 2010.
520 $a Monoterpenoids and their derivatives from plant essential oils show potential to be a good alternative to conventional insecticides due to their relatively high toxicity to insect pests, low toxicity to non-target organisms, and biodegradability in the environment. This dissertation has investigated the possible mechanisms of action of monoterpenoid insecticides in the insect nervous system, including an inhibitory neurotransmitter receptor, the GABA receptor, and an excitatory neurotransmitter, the nicotinic acetylcholine receptor (nAChR). By using radioligand binding assays, 36Cl- uptake assays, and quantitative structure-activity relationship assays, monoterpenoid insecticides were suggested to bind to these two receptors, and could interfere with the function of them in the nervous system, which might be the reason why these naturally occurring compounds have toxicity to insects. In the Chapter 2, carvacrol, pulegone, and thymol showed binding activities on insect GABA receptor, and inhibitory effects on the insect nervous system. In the Chapter 3, some structural and chemical properties of monoterpenoids, including Mulliken charges, log P values, and total energy levels, were indicated to be related to the binding between monoterpenoids and the insect GABA receptor. In the Chapter 4, a potent monoterpenoid insecticide, carvacrol, showed binding activity on insect nAChR at a new binding site. This dissertation will help us to understand the mechanism of action of monoterpenoid insecticides further, and is meaningful to discover and develop novel green insecticides.
590 $a School code: 0097.
650 4 $a Biology, Entomology. $3 1018619
650 4 $a Health Sciences, Toxicology. $3 1017752
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710 2 $a Iowa State University. $b Entomology. $3 1669158
773 0 $t Dissertation Abstracts International $g 72-03B.
790 1 0 $a Coats, Joel R., $e advisor
790 1 0 $a Day, Timothy $e committee member
790 1 0 $a Martin, Richard $e committee member
790 1 0 $a Jurenka, Russell $e committee member
790 1 0 $a Osweiler, Gary $e committee member
790 $a 0097
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3438739