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Investigations into mosquito-borne f...

Cox, Jonathan T.

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Investigations into mosquito-borne flavivirus control through the exploration of molecular and ecological interactions.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Investigations into mosquito-borne flavivirus control through the exploration of molecular and ecological interactions./
Author:	Cox, Jonathan T.
Description:	257 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-07, Section: B, page: 4206.
Contained By:	Dissertation Abstracts International71-07B.
Subject:	Biology, Entomology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3414996
ISBN:	9781124089058

Investigations into mosquito-borne flavivirus control through the exploration of molecular and ecological interactions.
Cox, Jonathan T.

Investigations into mosquito-borne flavivirus control through the exploration of molecular and ecological interactions. - 257 p.

Source: Dissertation Abstracts International, Volume: 71-07, Section: B, page: 4206.

Thesis (Ph.D.)--Yale University, 2010.

Flaviviruses, including dengue virus, yellow fever virus, and West Nile virus, are among the most important and common vector-borne infectious diseases to public health throughout the tropic and subtropical world. Although they continue to expand their geographic range and human incidence continues to rise, little is known about the interactions between these viruses and their invertebrate hosts. Chapter 1 of this dissertation provides background on these three flaviviruses and discusses strategies for control. Chapter 2 presents results from proteomic analysis identifying differentially expressed proteins during flavivirus infection in insect in vivo and in vitro systems. Pathway and network analysis are used to identify several cellular pathways that may be important during viral replication in the arthropod host, and successful identification of known proteins and cellular pathways demonstrates the validity of our combined proteomic and transcriptional assays. In Chapter 3, we investigate apoptosis, one of the cellular processes identified in Chapter 2 as significant in mosquito responses to flavivirus infection, through in vivo use of siRNA to activate the RNAi pathway against specific genes resulting in transient gene knockout. This is the first use of siRNA in whole mosquitoes and the first direct demonstration that modulation of the apoptosis pathway directly effects the replication of flaviviruses in mosquitoes. Finally, in Chapter 4 differential distributions of Aedes aegypti, Ae. mediovittatus and other mosquitoes along an urban-rural and altitudinal gradient in San Juan, Puerto Rico are reported. Aedes species extensively overlapped in low density housing areas, which has implications for dengue persistence. Together these chapters expand current molecular and ecological knowledge concerning mosquito-borne flavivirus infections. Better control of flaviviruses will be achieved through limiting flavivirus infection in mosquitoes and targeting environments in which humans are at greatest risk.

ISBN: 9781124089058Subjects--Topical Terms:

1018619
Biology, Entomology.

Investigations into mosquito-borne flavivirus control through the exploration of molecular and ecological interactions.
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035 $a (UMI)AAI3414996
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100 1 $a Cox, Jonathan T. $3 1675601
245 1 0 $a Investigations into mosquito-borne flavivirus control through the exploration of molecular and ecological interactions.
300 $a 257 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-07, Section: B, page: 4206.
500 $a Adviser: Erol Fikrig.
502 $a Thesis (Ph.D.)--Yale University, 2010.
520 $a Flaviviruses, including dengue virus, yellow fever virus, and West Nile virus, are among the most important and common vector-borne infectious diseases to public health throughout the tropic and subtropical world. Although they continue to expand their geographic range and human incidence continues to rise, little is known about the interactions between these viruses and their invertebrate hosts. Chapter 1 of this dissertation provides background on these three flaviviruses and discusses strategies for control. Chapter 2 presents results from proteomic analysis identifying differentially expressed proteins during flavivirus infection in insect in vivo and in vitro systems. Pathway and network analysis are used to identify several cellular pathways that may be important during viral replication in the arthropod host, and successful identification of known proteins and cellular pathways demonstrates the validity of our combined proteomic and transcriptional assays. In Chapter 3, we investigate apoptosis, one of the cellular processes identified in Chapter 2 as significant in mosquito responses to flavivirus infection, through in vivo use of siRNA to activate the RNAi pathway against specific genes resulting in transient gene knockout. This is the first use of siRNA in whole mosquitoes and the first direct demonstration that modulation of the apoptosis pathway directly effects the replication of flaviviruses in mosquitoes. Finally, in Chapter 4 differential distributions of Aedes aegypti, Ae. mediovittatus and other mosquitoes along an urban-rural and altitudinal gradient in San Juan, Puerto Rico are reported. Aedes species extensively overlapped in low density housing areas, which has implications for dengue persistence. Together these chapters expand current molecular and ecological knowledge concerning mosquito-borne flavivirus infections. Better control of flaviviruses will be achieved through limiting flavivirus infection in mosquitoes and targeting environments in which humans are at greatest risk.
590 $a School code: 0265.
650 4 $a Biology, Entomology. $3 1018619
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0353
690 $a 0573
710 2 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 71-07B.
790 1 0 $a Fikrig, Erol, $e advisor
790 $a 0265
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3414996