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Moderator effects of working memory ...

Trampush, Joey W.

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Moderator effects of working memory on symptom stability in attention-deficit/hyperactivity disorder by dopamine D1 and D2 receptor polymorphisms during development.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Moderator effects of working memory on symptom stability in attention-deficit/hyperactivity disorder by dopamine D1 and D2 receptor polymorphisms during development./
Author:	Trampush, Joey W.
Description:	145 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-11, Section: B, page: .
Contained By:	Dissertation Abstracts International71-11B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3426882
ISBN:	9781124293028

Moderator effects of working memory on symptom stability in attention-deficit/hyperactivity disorder by dopamine D1 and D2 receptor polymorphisms during development.
Trampush, Joey W.

Moderator effects of working memory on symptom stability in attention-deficit/hyperactivity disorder by dopamine D1 and D2 receptor polymorphisms during development. - 145 p.

Source: Dissertation Abstracts International, Volume: 71-11, Section: B, page: .

Thesis (Ph.D.)--City University of New York, 2010.

Background. Developmental changes in dopaminergic pathways in the prefrontal cortex (PFC) that are important for working memory have been hypothesized to play a central role in the trajectory of attention-deficit/hyperactivity disorder (ADHD), but not the initial onset of the disorder. This dissertation research examines whether dopamine receptor D1 (DRD1) and dopamine receptor D2 (DRD2) gene polymorphisms moderate the association between improvements in working memory and declines in attention problems in ADHD from childhood to adolescence/young adulthood. Methods. Participants were 76 racially/ethnically diverse youth diagnosed with ADHD in childhood and followed prospectively for almost 10 years. Stability of ADHD symptomatology was measured as a quantitative trait using the Attention Problems scale from the Child Behavior Checklist collected both in childhood and adolescence/young adulthood. Digit Span Forward and Digit Span Backward were administered at both time points to assess working memory maintenance and manipulation, respectively. Genotype and age were moderator variables. Results. DRD1 and DRD2 polymorphisms were associated with the stability of attention problems in adolescence/young adulthood, but not childhood. DRD1 polymorphisms, but not DRD2, significantly moderated the association between working memory and attention problems, with the strongest effects evidenced during adolescence/young adulthood. Notably, DRD1 moderation of working memory on attention problems was specific to manipulation performance. Conclusions. Attention problems decreased over the course of almost 10 years if manipulation concomitantly improved during this period of development in a subgroup of individuals with childhood-diagnosed ADHD depending on their genetic makeup.

ISBN: 9781124293028Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Moderator effects of working memory on symptom stability in attention-deficit/hyperactivity disorder by dopamine D1 and D2 receptor polymorphisms during development.
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020 $a 9781124293028
035 $a (UMI)AAI3426882
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100 1 $a Trampush, Joey W. $3 1673249
245 1 0 $a Moderator effects of working memory on symptom stability in attention-deficit/hyperactivity disorder by dopamine D1 and D2 receptor polymorphisms during development.
300 $a 145 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-11, Section: B, page: .
500 $a Adviser: Jeffrey M. Halperin.
502 $a Thesis (Ph.D.)--City University of New York, 2010.
520 $a Background. Developmental changes in dopaminergic pathways in the prefrontal cortex (PFC) that are important for working memory have been hypothesized to play a central role in the trajectory of attention-deficit/hyperactivity disorder (ADHD), but not the initial onset of the disorder. This dissertation research examines whether dopamine receptor D1 (DRD1) and dopamine receptor D2 (DRD2) gene polymorphisms moderate the association between improvements in working memory and declines in attention problems in ADHD from childhood to adolescence/young adulthood. Methods. Participants were 76 racially/ethnically diverse youth diagnosed with ADHD in childhood and followed prospectively for almost 10 years. Stability of ADHD symptomatology was measured as a quantitative trait using the Attention Problems scale from the Child Behavior Checklist collected both in childhood and adolescence/young adulthood. Digit Span Forward and Digit Span Backward were administered at both time points to assess working memory maintenance and manipulation, respectively. Genotype and age were moderator variables. Results. DRD1 and DRD2 polymorphisms were associated with the stability of attention problems in adolescence/young adulthood, but not childhood. DRD1 polymorphisms, but not DRD2, significantly moderated the association between working memory and attention problems, with the strongest effects evidenced during adolescence/young adulthood. Notably, DRD1 moderation of working memory on attention problems was specific to manipulation performance. Conclusions. Attention problems decreased over the course of almost 10 years if manipulation concomitantly improved during this period of development in a subgroup of individuals with childhood-diagnosed ADHD depending on their genetic makeup.
590 $a School code: 0046.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Psychology, Clinical. $3 524864
650 4 $a Psychology, Cognitive. $3 1017810
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710 2 $a City University of New York. $b Psychology. $3 1025517
773 0 $t Dissertation Abstracts International $g 71-11B.
790 1 0 $a Halperin, Jeffrey M., $e advisor
790 1 0 $a Flory, Janine $e committee member
790 1 0 $a Hurd, Yasmin $e committee member
790 $a 0046
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3426882