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Three Dimensional Diffuse Optical Sp...

Liu, Jing.

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Three Dimensional Diffuse Optical Spectroscopic Imaging in Reflectance Geometry.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Three Dimensional Diffuse Optical Spectroscopic Imaging in Reflectance Geometry./
Author:	Liu, Jing.
Description:	107 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-02, Section: B, page: .
Contained By:	Dissertation Abstracts International72-02B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3434284
ISBN:	9781124410302

Three Dimensional Diffuse Optical Spectroscopic Imaging in Reflectance Geometry.
Liu, Jing.

Three Dimensional Diffuse Optical Spectroscopic Imaging in Reflectance Geometry. - 107 p.

Source: Dissertation Abstracts International, Volume: 72-02, Section: B, page: .

Thesis (Ph.D.)--University of California, Irvine, 2010.

Diffusive near infrared (NIR) photons report on subsurface biological tissue structure and function. Diffuse optical techniques, such as diffuse optical imaging (DOI) and diffuse optical spectroscopy (DOS), adopt model-based approaches to quantitatively extract spatial and spectral information content from centimeter thick tissues. In diffuse optical techniques, NIR photons that have diffusively probed the tissue are collected on tissue boundaries.

ISBN: 9781124410302Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Three Dimensional Diffuse Optical Spectroscopic Imaging in Reflectance Geometry.
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020 $a 9781124410302
035 $a (UMI)AAI3434284
035 $a AAI3434284
040 $a UMI $c UMI
100 1 $a Liu, Jing. $3 1027965
245 1 0 $a Three Dimensional Diffuse Optical Spectroscopic Imaging in Reflectance Geometry.
300 $a 107 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-02, Section: B, page: .
500 $a Advisers: Thorsten Ritz; Bruce Tromberg.
502 $a Thesis (Ph.D.)--University of California, Irvine, 2010.
520 $a Diffusive near infrared (NIR) photons report on subsurface biological tissue structure and function. Diffuse optical techniques, such as diffuse optical imaging (DOI) and diffuse optical spectroscopy (DOS), adopt model-based approaches to quantitatively extract spatial and spectral information content from centimeter thick tissues. In diffuse optical techniques, NIR photons that have diffusively probed the tissue are collected on tissue boundaries.
520 $a The current DOS technique developed in the Tromberg research group focuses on characterizing tissue heterogeneities (i.e., tumors) by using a large spectral bandwidth (i.e., &sim; thousand NIR wavelengths ranging from 650 to 1000 nm). This high spectral density of broadband DOS allows the recovery of important NIR-absorbing molecule concentrations and states, as well as identification of spectral signatures unique to tissue heterogeneities. The current DOS instrument employs a single spatial view (i.e., one source and detector pair) in a reflectance geometry.
520 $a DOS suffers from poor accuracy in recovering the spatial location and the optical properties of heterogeneities because of the single spatial view and the application of a simple homogeneous model. In this work, I am devoted to developing new imaging approaches that will improve the spatial capabilities of DOS while keeping its rich broadband spectral bandwidth and reflectance configuration. Reflectance imaging is also challenging because the field of view is less than the conventional ring geometries in tomography and parallel plate geometries used in transmittance imaging.
520 $a I will first describe how the spatial extent of subsurface structure is assessed with current DOS technology independent of any image reconstruction. This spatial information serves as a physiologically relevant spatial constraint, known as a spatial a priori, for subsequent image reconstruction algorithms. Next I will describe a novel imaging approach that takes advantage of this spatial information is introduced. It has the potential of being used for fast and reliable recovery of optical properties in clinical settings. Lastly, in addition to the use of spatial a priori in the reconstruction algorithm, a reflectance measurement scheme with extra source-detector pairs and more tissue spatial views is proposed and developed. With spatial information obtained through spatial a priori or additional spatial measurements, the new imaging method is capable of accurately extracting both spatial and spectral content, even in a reflectance measurement geometry.
590 $a School code: 0030.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Radiology. $3 1019076
650 4 $a Physics, Optics. $3 1018756
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0541
690 $a 0574
690 $a 0752
690 $a 0760
710 2 $a University of California, Irvine. $b Physics - Ph.D. $3 1672409
773 0 $t Dissertation Abstracts International $g 72-02B.
790 1 0 $a Ritz, Thorsten, $e advisor
790 1 0 $a Tromberg, Bruce, $e advisor
790 1 0 $a Gulsen, Gultekin $e committee member
790 $a 0030
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3434284