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The effects of orally administered c...

Samson, Kaeli K.

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The effects of orally administered capsaicin in neonatal and adult rats on fungiform taste buds and papillae morphology.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The effects of orally administered capsaicin in neonatal and adult rats on fungiform taste buds and papillae morphology./
Author:	Samson, Kaeli K.
Description:	45 p.
Notes:	Source: Masters Abstracts International, Volume: 48-04, page: 2519.
Contained By:	Masters Abstracts International48-04.
Subject:	Psychology, Psychobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1474875
ISBN:	9781109710519

The effects of orally administered capsaicin in neonatal and adult rats on fungiform taste buds and papillae morphology.
Samson, Kaeli K.

The effects of orally administered capsaicin in neonatal and adult rats on fungiform taste buds and papillae morphology. - 45 p.

Source: Masters Abstracts International, Volume: 48-04, page: 2519.

Thesis (M.A.)--University of Nebraska at Omaha, 2010.

In the past, research on gustatory and associated somatosensory nerve injury has utilized surgeries (e.g. Hard af Segerstad et al., 1989) and systemic injections of chemicals (e.g. Ganchrow et al., 1992). The current study was designed to identify the effects of a more naturalistic approach to nerve injury by orally administering capsaicin, the spicy chemical found in peppers, which is known to denervate certain subsets of neurons (Polydefkis et al., 2004). Rats received either a capsaicin in sucrose (CAP) or a control sucrose (SUC) solution every day for 36 days, starting at either 5 days of age (P5; neonates) or P44/45 (adults). Animals were then sacrificed either immediately (i.e. 2 days) after treatment, or 50 days post treatment to allow for possible recovery. Taste bud volumes were measured and classification of papillae morphology was noted. No difference in papillae morphology or overall number of papillae existed between the CAP and SUC groups at any time point. Differences in taste bud volumes were found in adults sacrificed 50 days post treatment, where the CAP animals had significantly smaller taste buds than the SUC animals; no differences in taste bud volumes were found in adults sacrificed 2 days post treatment, or in neonates at either time point. These results diverge from previous literature which found that neonates who had their lingual nerve transected (the same nerve that capsaicin is known to affect (Nagy et al., 1982)) had greater gustatory losses than rats who received the same transection as adults (Gomez & Sollars, 2006). Reasons for this discrepancy may have to do with the dissimilarity of the two types of injury (surgical vs. chemical), as well as interactions with the physiological milieu of the tongue and/or methodological limitations.

ISBN: 9781109710519Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

The effects of orally administered capsaicin in neonatal and adult rats on fungiform taste buds and papillae morphology.
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020 $a 9781109710519
035 $a (UMI)AAI1474875
035 $a AAI1474875
040 $a UMI $c UMI
100 1 $a Samson, Kaeli K. $3 1669126
245 1 4 $a The effects of orally administered capsaicin in neonatal and adult rats on fungiform taste buds and papillae morphology.
300 $a 45 p.
500 $a Source: Masters Abstracts International, Volume: 48-04, page: 2519.
500 $a Adviser: Suzanne Sollars.
502 $a Thesis (M.A.)--University of Nebraska at Omaha, 2010.
520 $a In the past, research on gustatory and associated somatosensory nerve injury has utilized surgeries (e.g. Hard af Segerstad et al., 1989) and systemic injections of chemicals (e.g. Ganchrow et al., 1992). The current study was designed to identify the effects of a more naturalistic approach to nerve injury by orally administering capsaicin, the spicy chemical found in peppers, which is known to denervate certain subsets of neurons (Polydefkis et al., 2004). Rats received either a capsaicin in sucrose (CAP) or a control sucrose (SUC) solution every day for 36 days, starting at either 5 days of age (P5; neonates) or P44/45 (adults). Animals were then sacrificed either immediately (i.e. 2 days) after treatment, or 50 days post treatment to allow for possible recovery. Taste bud volumes were measured and classification of papillae morphology was noted. No difference in papillae morphology or overall number of papillae existed between the CAP and SUC groups at any time point. Differences in taste bud volumes were found in adults sacrificed 50 days post treatment, where the CAP animals had significantly smaller taste buds than the SUC animals; no differences in taste bud volumes were found in adults sacrificed 2 days post treatment, or in neonates at either time point. These results diverge from previous literature which found that neonates who had their lingual nerve transected (the same nerve that capsaicin is known to affect (Nagy et al., 1982)) had greater gustatory losses than rats who received the same transection as adults (Gomez & Sollars, 2006). Reasons for this discrepancy may have to do with the dissimilarity of the two types of injury (surgical vs. chemical), as well as interactions with the physiological milieu of the tongue and/or methodological limitations.
590 $a School code: 1060.
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0349
710 2 $a University of Nebraska at Omaha. $b Psychology. $3 1263887
773 0 $t Masters Abstracts International $g 48-04.
790 1 0 $a Sollars, Suzanne, $e advisor
790 1 0 $a Rodriguez-Sierra, Jorge $e committee member
790 1 0 $a Strasser, Rosemary $e committee member
790 $a 1060
791 $a M.A.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1474875