東華大學圖書館 |

Gene therapy of the central nervous system = from bench to bedside /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Gene therapy of the central nervous system/ [edited by] Michael G. Kaplitt and Matthew J. During.{me_controlnum}
Reminder of title:	from bench to bedside /
other author:	Kaplitt, Michael G.
Published:	Amsterdam ;Academic Press, : 2006.,
Description:	1 online resource (xiv, 355 p.) :ill. (some col.)
[NT 15003449]:	SECTION I. GENE TRANSFER TECHNOLOGY AND REGULATORY ISSUES -- 1. Design and optimization of expression cassettes including promoter choice and regulatory lements -- 2. Identification of Novel AAV Serotypes for Use as Vectors -- 3. HSV amplicon vectors for gene delivery to the nervous system -- 4. Influence of the immune system on CNS gene transfer -- 5. Targeted induction of endogenous neural stem and progenitor cells: A new strategy for gene therapy of neurological disease -- 6. Neurosurgical Targeting, Delivery and Infusion of Gene Therapy Agents in the Brain -- 7. Gene Transfer for Neurological Disease: Agencies, Policies and Process -- SECTION II. GENE THERAPY FOR DEGENERATIVE AND FUNCTIONAL DISORDERS -- 8. Gene therapy for Parkinsons disease -- 9. Non human primate models for testing gene therapy for neurodegenerative disorders -- 10. Delivery of Molecular Therapeutics into the CNS and their Distribution within the Brain -- 11. Gene therapy for CNS diseases using intrabodies -- 12. Gene therapy for epilepsy -- SECTION IIII. PSYCHIATRIC AND BEHAVIORAL GENE THERAPY -- 13. Genetic manipulation of learning and memory -- 14. Psychiatric applications of viral vectors -- 15. Use of viral vectors to influencebehavior -- SECTION IV. GENE THERAPY FOR PAIN AND SPINAL CORD DISEASES -- 16. Herpes simplex vector mediated gene transfer to the peripheralnervous system for the treatment of polyneuropathy and chronic pain -- 17. Characterization of pain receptors in the spinal cord using a viral vector for spatial-temportal gene targeting -- 18. Viral vector mediated gene therapy of pain -- 19. VEGF, an angiogenic factor with neurotrophic activity, useful for treatment of ALS? -- 20. Viral Vector Axonal Uptake and Retrograde Transport: Mechanisms and Applications -- 21. Gene therapy for spinal cord injury -- V. GENE THERAPY FOR BRAIN TUMORS AND NEUROGENETIC DISEASES -- 22. Prodrug-Activation Gene Therapy -- 23. Clinical trials of gene therapy for Canavan Disease -- 24. Gene therapy for the late infantile form of Batten disease -- 25. Molecular Imaging of Gene Therapy for Neurogenetic Diseases.
Subject:	Nervous system - Diseases -
Online resource:	http://www.sciencedirect.com/science/book/9780123976321
ISBN:	9780123976321

Gene therapy of the central nervous system = from bench to bedside /
Gene therapy of the central nervous systemfrom bench to bedside /[electronic resource] :[edited by] Michael G. Kaplitt and Matthew J. During.{me_controlnum} - Amsterdam ;Academic Press,2006. - 1 online resource (xiv, 355 p.) :ill. (some col.)

Includes bibliographical references and index.

SECTION I. GENE TRANSFER TECHNOLOGY AND REGULATORY ISSUES -- 1. Design and optimization of expression cassettes including promoter choice and regulatory lements -- 2. Identification of Novel AAV Serotypes for Use as Vectors -- 3. HSV amplicon vectors for gene delivery to the nervous system -- 4. Influence of the immune system on CNS gene transfer -- 5. Targeted induction of endogenous neural stem and progenitor cells: A new strategy for gene therapy of neurological disease -- 6. Neurosurgical Targeting, Delivery and Infusion of Gene Therapy Agents in the Brain -- 7. Gene Transfer for Neurological Disease: Agencies, Policies and Process -- SECTION II. GENE THERAPY FOR DEGENERATIVE AND FUNCTIONAL DISORDERS -- 8. Gene therapy for Parkinsons disease -- 9. Non human primate models for testing gene therapy for neurodegenerative disorders -- 10. Delivery of Molecular Therapeutics into the CNS and their Distribution within the Brain -- 11. Gene therapy for CNS diseases using intrabodies -- 12. Gene therapy for epilepsy -- SECTION IIII. PSYCHIATRIC AND BEHAVIORAL GENE THERAPY -- 13. Genetic manipulation of learning and memory -- 14. Psychiatric applications of viral vectors -- 15. Use of viral vectors to influencebehavior -- SECTION IV. GENE THERAPY FOR PAIN AND SPINAL CORD DISEASES -- 16. Herpes simplex vector mediated gene transfer to the peripheralnervous system for the treatment of polyneuropathy and chronic pain -- 17. Characterization of pain receptors in the spinal cord using a viral vector for spatial-temportal gene targeting -- 18. Viral vector mediated gene therapy of pain -- 19. VEGF, an angiogenic factor with neurotrophic activity, useful for treatment of ALS? -- 20. Viral Vector Axonal Uptake and Retrograde Transport: Mechanisms and Applications -- 21. Gene therapy for spinal cord injury -- V. GENE THERAPY FOR BRAIN TUMORS AND NEUROGENETIC DISEASES -- 22. Prodrug-Activation Gene Therapy -- 23. Clinical trials of gene therapy for Canavan Disease -- 24. Gene therapy for the late infantile form of Batten disease -- 25. Molecular Imaging of Gene Therapy for Neurogenetic Diseases.

Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use.

ISBN: 9780123976321

Source: 91222:91221Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

683084
Nervous system
--DiseasesIndex Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RC350.G45 / G46 2006

Dewey Class. No.: 616.8/046

National Library of Medicine Call No.: 2006 B-351

Gene therapy of the central nervous system = from bench to bedside /
LDR:05606cmm 2200493Ia 4500 001 1325884
005 20120813090649.0
006 m d
007 cr cn|||||||||
008 130122s2006 ne a ob 001 0 eng d
019 $a 74908110 $a 85782405 $a 144219692 $a 232311585 $a 271462260 $a 609274113
020 $a 9780123976321
020 $a 0123976324
020 $a 661063792X (electronic bk.)
020 $a 9786610637928 (electronic bk.)
020 $a 0080454372 (electronic bk.)
020 $a 9780080454375 (electronic bk.)
029 1 $a NZ1 $b 12434131
029 1 $a CDX $b 5672042
029 1 $a AU@ $b 000042525384
029 1 $a DEBBG $b BV039831371
035 $a ocn162129568
037 $a 91222:91221 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $b eng $c OPELS $d OPELS $d OCLCQ $d CDX $d N$T $d YDXCP $d OCLCE $d E7B $d EBLCP $d BTCTA $d MHW $d IDEBK $d OCLCQ
049 $a NTYA
050 4 $a RC350.G45 $b G46 2006
060 4 $a 2006 B-351
060 4 $a WL 300 $b G32624 2006
072 7 $a HEA $x 039110 $2 bisacsh
072 7 $a MED $x 056000 $2 bisacsh
082 0 4 $a 616.8/046 $2 22
245 0 0 $a Gene therapy of the central nervous system $h [electronic resource] : $b from bench to bedside / $c [edited by] Michael G. Kaplitt and Matthew J. During.{me_controlnum}
260 $a Amsterdam ; $a Boston : $b Academic Press, $c 2006.
300 $a 1 online resource (xiv, 355 p.) : $b ill. (some col.)
504 $a Includes bibliographical references and index.
505 0 $a SECTION I. GENE TRANSFER TECHNOLOGY AND REGULATORY ISSUES -- 1. Design and optimization of expression cassettes including promoter choice and regulatory lements -- 2. Identification of Novel AAV Serotypes for Use as Vectors -- 3. HSV amplicon vectors for gene delivery to the nervous system -- 4. Influence of the immune system on CNS gene transfer -- 5. Targeted induction of endogenous neural stem and progenitor cells: A new strategy for gene therapy of neurological disease -- 6. Neurosurgical Targeting, Delivery and Infusion of Gene Therapy Agents in the Brain -- 7. Gene Transfer for Neurological Disease: Agencies, Policies and Process -- SECTION II. GENE THERAPY FOR DEGENERATIVE AND FUNCTIONAL DISORDERS -- 8. Gene therapy for Parkinsons disease -- 9. Non human primate models for testing gene therapy for neurodegenerative disorders -- 10. Delivery of Molecular Therapeutics into the CNS and their Distribution within the Brain -- 11. Gene therapy for CNS diseases using intrabodies -- 12. Gene therapy for epilepsy -- SECTION IIII. PSYCHIATRIC AND BEHAVIORAL GENE THERAPY -- 13. Genetic manipulation of learning and memory -- 14. Psychiatric applications of viral vectors -- 15. Use of viral vectors to influencebehavior -- SECTION IV. GENE THERAPY FOR PAIN AND SPINAL CORD DISEASES -- 16. Herpes simplex vector mediated gene transfer to the peripheralnervous system for the treatment of polyneuropathy and chronic pain -- 17. Characterization of pain receptors in the spinal cord using a viral vector for spatial-temportal gene targeting -- 18. Viral vector mediated gene therapy of pain -- 19. VEGF, an angiogenic factor with neurotrophic activity, useful for treatment of ALS? -- 20. Viral Vector Axonal Uptake and Retrograde Transport: Mechanisms and Applications -- 21. Gene therapy for spinal cord injury -- V. GENE THERAPY FOR BRAIN TUMORS AND NEUROGENETIC DISEASES -- 22. Prodrug-Activation Gene Therapy -- 23. Clinical trials of gene therapy for Canavan Disease -- 24. Gene therapy for the late infantile form of Batten disease -- 25. Molecular Imaging of Gene Therapy for Neurogenetic Diseases.
520 $a Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use.
588 $a Description based on print version record.
650 0 $a Nervous system $x Diseases $x Gene therapy. $3 683084
650 1 2 $a Genetic Vectors. $3 867641
650 2 2 $a Central Nervous System Diseases $x genetics. $3 1614392
650 2 2 $a Central Nervous System Diseases $x therapy. $3 1361936
650 2 2 $a Central Nervous System $x physiology. $3 691162
650 2 2 $a Genes, Viral $x genetics. $3 1614393
650 2 2 $a Gene Expression Regulation, Viral. $3 705835
650 2 2 $a Gene Therapy. $3 600618
650 7 $a HEALTH & FITNESS $x Diseases $x Nervous System (incl. Brain) $2 bisacsh $3 1362463
650 7 $a MEDICAL $x Neurology. $2 bisacsh $3 1362464
655 4 $a Electronic books. $2 lcsh $3 542853
700 1 $a Kaplitt, Michael G. $3 1614390
700 1 $a During, Matthew J. $3 1614391
776 0 8 $i Print version: $t Gene therapy of the central nervous system. $d Amsterdam ; Boston : Academic Press, 2006 $z 0123976324 $z 9780123976321 $w (OCoLC)65360708
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780123976321
938 $a Coutts Information Services $b COUT $n 5672042 $c 109.44 GBP
938 $a YBP Library Services $b YANK $n 2485363
938 $a ebrary $b EBRY $n ebr10138312
938 $a Baker and Taylor $b BTCP $n BK0007038906
938 $a Ingram Digital eBook Collection $b IDEB $n 63792