東華大學圖書館 |

Principles of bone biology

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Principles of bone biology/ edited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.{me_controlnum}
其他作者:	Bilezikian, John P.
出版者:	San Diego :Academic Press, : c2002.,
面頁冊數:	2 v. (xxiv, 1696 p.) :ill. ;29 cm.
內容註:	PART I: BASIC PRINCIPLES -- Cell Biology -- The Structure & Development of the Skeleton -- Biomechanics of Bone -- Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation -- Mesenchymal Stem Cells & Osteoblast Lineage -- Transcriptional Control of Osteoblast Differentiation and Function -- The Osteocyte -- Cells of Bone: Osteoclast Generation -- Osteoclast Function -- Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts -- Apoptosis in Bone Cells -- Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells -- Biochemistry -- Type I Collagen: Structure, Synthesis, and Regulation -- Collagen Crosslinking & Metabolism -- Bone Matrix Proteoglycans & Glycoproteins -- Osteopontin -- Bone Proteinases -- Cell Surface Attachment Molecules -- Intercellular Junctions and Cell-Cell Communication in Bone -- Bone Remodeling and Mineral Homeostasis -- Histomorphometric Analysis of Bone Remodeling -- Phosphorus Homeostasis & Related Disorders -- Magnesium Homeostasis -- Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium -- The Biology of the Extracellular Ca2+-Sensing Receptor (CaR) -- The Hormones of Bone -- Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide -- Parathyroid Hormone -- Molecular Biology -- Parathyroid Hormone-Receptor Interactions -- Actions of Parathyroid Hormone -- Renal and Skeletal Actions of PTH and PTHrP -- Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues -- Vascular, Cardiovascular and Neurological Actions of PTHrP -- Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses -- Vitamin D Gene Regulation -- Photobiology and Non-Calcemic Actions of Vitamin D -- The Structure and Molecular Biology of the Calcitonin Receptor -- Physiology & Pathophysiology of Calcitonin -- Amylin & CGRP -- Other Systemic Hormones That Influence Bone Metabolism -- Estrogens & Progestins -- Selective Estrogen Receptor Modulators (SERMs) -- Mechanisms of Estrogen Action in Bone -- Thyroid Hormone & Bone -- Clinical and Basic Aspects of Glucocorticoid Action in Bone -- Effects of Diabetes & Insulin on Bone Physiology -- Androgens: Receptor Expression and Steroid Action in Bone -- Kinins & Neuro-Osteogenic Factors -- Local Regulators -- The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology -- Platelet-Derived Growth Factor & the Skeleton -- Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone -- Vascular Endothelial Growth Factors -- Transforming Growth Factor (beta) -- Bone Morphogenetic Proteins -- Bone Morphogenetic Protein Receptors & Actions -- Colony-Stimulating Factors -- Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines -- Prostaglandins & Bone Metabolism -- Nitric Oxide and other Vasoactive Agents -- PART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASES -- Molecular Basis of PTH Overexpression -- Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism -- Multiple Endocrine Neoplasia Type I -- The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2 -- Systemic Factors in Skeletal Manifestations of Malignancy -- Local Factors in Skeletal Malignancy -- Molecular Basis of PTH Underexpression -- Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations -- Signal Transduction via G Proteins; Pseudohypoparathyroidism -- Other Skeletal Diseases Resulting from G Protein Defects -- Fibrous Dysplasia & McCune-Albright Syndrome -- Osteogenesis Imperfecta -- Hereditary Deficiencies in Vitamin D Action. -- Oncogenic Osteomalacia -- Osteopetrosis -- Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man -- Paget's Disease of Bone -- Genetic Determinants of Bone Mass -- Pathophysiology of Osteoporosis -- Evaluation of Risk for Osteoporosis Fractures -- PART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICS -- Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone -- Calcium -- Calcium Receptors as Novel Drug Targets -- Bisphosphonates: Mechanisms of Action -- Fluoride in Osteoporosis -- The Pharmacology of Estrogens in Osteoporosis -- Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs -- Molecular and Clinical Pharmacology of Calcitonin -- Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases -- Anabolic Steroid Effects on Bone in Women -- Estrogen Effects on Bone in the Male Skeleton -- Mechanisms of Exercise Effects on Bone -- PART IV: METHODS IN BONE RESEARCH -- Application of Transgenic Mice to Problems of Skeletal Bone -- Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes -- Current Methodologic Issues in Cell & Tissue Culture -- Biochemical Markers of Bone Metabolism -- Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry -- Controversies in Bone Mass Measurement -- Macro and Micro Imaging of Bone Architecture -- Transilial Bone Biopsy -- Animal Models in Osteoporosis Research -- Defining the Genetics of Osteoporosis -- Using the Mouse to Understand Man.
內容註:	V. 1.-- Part. I. Basic principles -- V. 2.-- Part. II. Molecular mechanisims of metabolic bone diseases -- Part. III. Pharmacological mechanisms of therapeutics -- Part. IV. Methods in bone research.
標題:	Bones - Physiology. -
電子資源:	http://www.sciencedirect.com/science/book/9780120986521An electronic book accessible through the World Wide Web; click for information
ISBN:	9780120986521

Principles of bone biology
Principles of bone biology[electronic resource] /edited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.{me_controlnum} - 2nd ed. - San Diego :Academic Press,c2002. - 2 v. (xxiv, 1696 p.) :ill. ;29 cm.

Includes bibliographical references and index.

PART I: BASIC PRINCIPLES -- Cell Biology -- The Structure & Development of the Skeleton -- Biomechanics of Bone -- Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation -- Mesenchymal Stem Cells & Osteoblast Lineage -- Transcriptional Control of Osteoblast Differentiation and Function -- The Osteocyte -- Cells of Bone: Osteoclast Generation -- Osteoclast Function -- Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts -- Apoptosis in Bone Cells -- Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells -- Biochemistry -- Type I Collagen: Structure, Synthesis, and Regulation -- Collagen Crosslinking & Metabolism -- Bone Matrix Proteoglycans & Glycoproteins -- Osteopontin -- Bone Proteinases -- Cell Surface Attachment Molecules -- Intercellular Junctions and Cell-Cell Communication in Bone -- Bone Remodeling and Mineral Homeostasis -- Histomorphometric Analysis of Bone Remodeling -- Phosphorus Homeostasis & Related Disorders -- Magnesium Homeostasis -- Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium -- The Biology of the Extracellular Ca2+-Sensing Receptor (CaR) -- The Hormones of Bone -- Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide -- Parathyroid Hormone -- Molecular Biology -- Parathyroid Hormone-Receptor Interactions -- Actions of Parathyroid Hormone -- Renal and Skeletal Actions of PTH and PTHrP -- Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues -- Vascular, Cardiovascular and Neurological Actions of PTHrP -- Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses -- Vitamin D Gene Regulation -- Photobiology and Non-Calcemic Actions of Vitamin D -- The Structure and Molecular Biology of the Calcitonin Receptor -- Physiology & Pathophysiology of Calcitonin -- Amylin & CGRP -- Other Systemic Hormones That Influence Bone Metabolism -- Estrogens & Progestins -- Selective Estrogen Receptor Modulators (SERMs) -- Mechanisms of Estrogen Action in Bone -- Thyroid Hormone & Bone -- Clinical and Basic Aspects of Glucocorticoid Action in Bone -- Effects of Diabetes & Insulin on Bone Physiology -- Androgens: Receptor Expression and Steroid Action in Bone -- Kinins & Neuro-Osteogenic Factors -- Local Regulators -- The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology -- Platelet-Derived Growth Factor & the Skeleton -- Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone -- Vascular Endothelial Growth Factors -- Transforming Growth Factor (beta) -- Bone Morphogenetic Proteins -- Bone Morphogenetic Protein Receptors & Actions -- Colony-Stimulating Factors -- Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines -- Prostaglandins & Bone Metabolism -- Nitric Oxide and other Vasoactive Agents -- PART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASES -- Molecular Basis of PTH Overexpression -- Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism -- Multiple Endocrine Neoplasia Type I -- The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2 -- Systemic Factors in Skeletal Manifestations of Malignancy -- Local Factors in Skeletal Malignancy -- Molecular Basis of PTH Underexpression -- Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations -- Signal Transduction via G Proteins; Pseudohypoparathyroidism -- Other Skeletal Diseases Resulting from G Protein Defects -- Fibrous Dysplasia & McCune-Albright Syndrome -- Osteogenesis Imperfecta -- Hereditary Deficiencies in Vitamin D Action. -- Oncogenic Osteomalacia -- Osteopetrosis -- Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man -- Paget's Disease of Bone -- Genetic Determinants of Bone Mass -- Pathophysiology of Osteoporosis -- Evaluation of Risk for Osteoporosis Fractures -- PART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICS -- Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone -- Calcium -- Calcium Receptors as Novel Drug Targets -- Bisphosphonates: Mechanisms of Action -- Fluoride in Osteoporosis -- The Pharmacology of Estrogens in Osteoporosis -- Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs -- Molecular and Clinical Pharmacology of Calcitonin -- Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases -- Anabolic Steroid Effects on Bone in Women -- Estrogen Effects on Bone in the Male Skeleton -- Mechanisms of Exercise Effects on Bone -- PART IV: METHODS IN BONE RESEARCH -- Application of Transgenic Mice to Problems of Skeletal Bone -- Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes -- Current Methodologic Issues in Cell & Tissue Culture -- Biochemical Markers of Bone Metabolism -- Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry -- Controversies in Bone Mass Measurement -- Macro and Micro Imaging of Bone Architecture -- Transilial Bone Biopsy -- Animal Models in Osteoporosis Research -- Defining the Genetics of Osteoporosis -- Using the Mouse to Understand Man.

Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and pathology of bone Provides succinct coverage of the subject Contributors include over 200 of the most respected researchers in the field Extensive table of contents and index for easy reference Easy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacology Complete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780120986521

Source: 89583:89583Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

559226
Bones
--Physiology.Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: QP88.2 / .P735 2002eb

Dewey Class. No.: 612.7/5

National Agricultural Library Call No.: QP88.2 / .P735 2002

National Library of Medicine Call No.: 2002 B-275

Principles of bone biology
LDR:08500cmm 2200397Ia 4500 001 1032984
003 OCoLC
005 20110614113913.0
006 m d
007 cr cn|||||||||
008 120420s2002 caua ob 001 0 eng d
020 $a 9780120986521
020 $a 0120986523
029 1 $a NZ1 $b 12433317
035 $a (OCoLC)162570747
035 $a ocn162570747
037 $a 89583:89583 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $b eng $c OPELS $d OCLCG $d OCLCQ
049 $a TEFA
050 1 4 $a QP88.2 $b .P735 2002eb
060 1 4 $a 2002 B-275
060 1 4 $a WE 200 $b P957 2002
070 1 $a QP88.2 $b .P735 2002
072 0 $a X300
082 0 4 $a 612.7/5 $2 22
245 0 0 $a Principles of bone biology $h [electronic resource] / $c edited by John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan.{me_controlnum}
250 $a 2nd ed.
260 $a San Diego : $b Academic Press, $c c2002.
300 $a 2 v. (xxiv, 1696 p.) : $b ill. ; $c 29 cm.
504 $a Includes bibliographical references and index.
505 0 $a PART I: BASIC PRINCIPLES -- Cell Biology -- The Structure & Development of the Skeleton -- Biomechanics of Bone -- Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation -- Mesenchymal Stem Cells & Osteoblast Lineage -- Transcriptional Control of Osteoblast Differentiation and Function -- The Osteocyte -- Cells of Bone: Osteoclast Generation -- Osteoclast Function -- Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts -- Apoptosis in Bone Cells -- Involvement of Nuclear Architecture in Regulating Gene Expression in Bone Cells -- Biochemistry -- Type I Collagen: Structure, Synthesis, and Regulation -- Collagen Crosslinking & Metabolism -- Bone Matrix Proteoglycans & Glycoproteins -- Osteopontin -- Bone Proteinases -- Cell Surface Attachment Molecules -- Intercellular Junctions and Cell-Cell Communication in Bone -- Bone Remodeling and Mineral Homeostasis -- Histomorphometric Analysis of Bone Remodeling -- Phosphorus Homeostasis & Related Disorders -- Magnesium Homeostasis -- Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Strontium -- The Biology of the Extracellular Ca2+-Sensing Receptor (CaR) -- The Hormones of Bone -- Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Peptide -- Parathyroid Hormone -- Molecular Biology -- Parathyroid Hormone-Receptor Interactions -- Actions of Parathyroid Hormone -- Renal and Skeletal Actions of PTH and PTHrP -- Physiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic Issues -- Vascular, Cardiovascular and Neurological Actions of PTHrP -- Nuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological Responses -- Vitamin D Gene Regulation -- Photobiology and Non-Calcemic Actions of Vitamin D -- The Structure and Molecular Biology of the Calcitonin Receptor -- Physiology & Pathophysiology of Calcitonin -- Amylin & CGRP -- Other Systemic Hormones That Influence Bone Metabolism -- Estrogens & Progestins -- Selective Estrogen Receptor Modulators (SERMs) -- Mechanisms of Estrogen Action in Bone -- Thyroid Hormone & Bone -- Clinical and Basic Aspects of Glucocorticoid Action in Bone -- Effects of Diabetes & Insulin on Bone Physiology -- Androgens: Receptor Expression and Steroid Action in Bone -- Kinins & Neuro-Osteogenic Factors -- Local Regulators -- The Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell Biology -- Platelet-Derived Growth Factor & the Skeleton -- Fibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in Bone -- Vascular Endothelial Growth Factors -- Transforming Growth Factor (beta) -- Bone Morphogenetic Proteins -- Bone Morphogenetic Protein Receptors & Actions -- Colony-Stimulating Factors -- Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines -- Prostaglandins & Bone Metabolism -- Nitric Oxide and other Vasoactive Agents -- PART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASES -- Molecular Basis of PTH Overexpression -- Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism -- Multiple Endocrine Neoplasia Type I -- The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2 -- Systemic Factors in Skeletal Manifestations of Malignancy -- Local Factors in Skeletal Malignancy -- Molecular Basis of PTH Underexpression -- Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations -- Signal Transduction via G Proteins; Pseudohypoparathyroidism -- Other Skeletal Diseases Resulting from G Protein Defects -- Fibrous Dysplasia & McCune-Albright Syndrome -- Osteogenesis Imperfecta -- Hereditary Deficiencies in Vitamin D Action. -- Oncogenic Osteomalacia -- Osteopetrosis -- Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Man -- Paget's Disease of Bone -- Genetic Determinants of Bone Mass -- Pathophysiology of Osteoporosis -- Evaluation of Risk for Osteoporosis Fractures -- PART III: PHARMACOLOGIC MECHANISMS OF THERAPEUTICS -- Pharmacologic Mechanisms of Therapeutics: Parathyroid Hormone -- Calcium -- Calcium Receptors as Novel Drug Targets -- Bisphosphonates: Mechanisms of Action -- Fluoride in Osteoporosis -- The Pharmacology of Estrogens in Osteoporosis -- Pharmacologic Mechanisms of Therapeutics: Vitamin D & Analogs -- Molecular and Clinical Pharmacology of Calcitonin -- Growth Hormone and Insulin-like Growth Factor-I Treatment for Metabolic Bone Diseases -- Anabolic Steroid Effects on Bone in Women -- Estrogen Effects on Bone in the Male Skeleton -- Mechanisms of Exercise Effects on Bone -- PART IV: METHODS IN BONE RESEARCH -- Application of Transgenic Mice to Problems of Skeletal Bone -- Use of Cultured Osteoblastic Cells to Identify and Characterize Transcriptional Regulatory Complexes -- Current Methodologic Issues in Cell & Tissue Culture -- Biochemical Markers of Bone Metabolism -- Methods and Clinical Issues in Bone Densitometry and Quantitative Ultrasonometry -- Controversies in Bone Mass Measurement -- Macro and Micro Imaging of Bone Architecture -- Transilial Bone Biopsy -- Animal Models in Osteoporosis Research -- Defining the Genetics of Osteoporosis -- Using the Mouse to Understand Man.
505 0 $a V. 1.-- Part. I. Basic principles -- V. 2.-- Part. II. Molecular mechanisims of metabolic bone diseases -- Part. III. Pharmacological mechanisms of therapeutics -- Part. IV. Methods in bone research.
520 $a Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and pathology of bone Provides succinct coverage of the subject Contributors include over 200 of the most respected researchers in the field Extensive table of contents and index for easy reference Easy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacology Complete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Aug. 2, 2007). $n Access may be restricted to users at subscribing institutions.
650 0 $a Bones $x Physiology. $3 559226
650 0 $a Bones $x Molecular aspects. $3 802791
650 1 2 $a Bone and Bones $x physiology. $3 802793
650 2 2 $a Bone Diseases, Metabolic $x physiopathology. $3 1362014
650 2 2 $a Bone and Bones $x cytology. $3 802792
650 1 7 $a Bot (anatomie) $2 gtt $3 1362015
655 4 $a Electronic books. $2 lcsh $3 542853
700 1 $a Bilezikian, John P. $3 930052
700 1 $a Raisz, Lawrence G. $q (Lawrence Gideon), $d 1925- $3 1362012
700 1 $a Rodan, Gideon A. $3 1362013
710 2 $a ScienceDirect (Online service) $3 848416
776 1 $c Original $z 0120986523 $z 9780120986521 $z 0120986531 $z 9780120986538 $z 012098654X $z 9780120986545 $w (DLC) 2001090660 $w (OCoLC)48835873
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780120986521 $z An electronic book accessible through the World Wide Web; click for information
994 $a C0 $b TEF