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Regulation of Chromosome Dynamics by...

Shah, Nagma.

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Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants./
作者:	Shah, Nagma.
面頁冊數:	47 p.
附註:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
標題:	Oncology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1596932
ISBN:	9781321990362

Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.
Shah, Nagma.

Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants. - 47 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.S.)--Icahn School of Medicine at Mount Sinai, 2015.

Smc5/6 is one of three related complexes that regulate chromosome dynamics. It is closely related to cohesin, which encircles sister chromatids until anaphase. Cohesin is stripped from chromosomes in a two-step process: first, from chromosome arms at prophase by an unknown mechanism; second, centromeric cohesin is cleaved, enabling sister separation. Smc5/6-dysfunction leads to a failure of arm cohesin removal, causing mitotic defects. Loss of H2A.Z causes aneuploidy, reduces arm cohesin levels, and suppresses cohesin retention in Smc5/6 mutants. Canonical H2A with various post-translational modifications occupies regions that normally contain H2A.Z nucleosomes in these cells. I have explored a role of H2A in cohesin regulation, and found that gamma-H2A is critical for Smc5/6 mutants to survive DNA damage, and is increased in the absence of H2A.Z. Thus, the presence of gamma-H2A rather than the absence of H2A.Z may be critical in cohesin regulation, expanding the epigenetic control of the cohesin cycle.

ISBN: 9781321990362Subjects--Topical Terms:

751006
Oncology.

Regulation of Chromosome Dynamics by Histone Modifications and Histone Variants.
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500 $a Adviser: Matthew J. O'Connell.
502 $a Thesis (M.S.)--Icahn School of Medicine at Mount Sinai, 2015.
520 $a Smc5/6 is one of three related complexes that regulate chromosome dynamics. It is closely related to cohesin, which encircles sister chromatids until anaphase. Cohesin is stripped from chromosomes in a two-step process: first, from chromosome arms at prophase by an unknown mechanism; second, centromeric cohesin is cleaved, enabling sister separation. Smc5/6-dysfunction leads to a failure of arm cohesin removal, causing mitotic defects. Loss of H2A.Z causes aneuploidy, reduces arm cohesin levels, and suppresses cohesin retention in Smc5/6 mutants. Canonical H2A with various post-translational modifications occupies regions that normally contain H2A.Z nucleosomes in these cells. I have explored a role of H2A in cohesin regulation, and found that gamma-H2A is critical for Smc5/6 mutants to survive DNA damage, and is increased in the absence of H2A.Z. Thus, the presence of gamma-H2A rather than the absence of H2A.Z may be critical in cohesin regulation, expanding the epigenetic control of the cohesin cycle.
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