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[ subject:"Neurosciences." ]
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The Effects of Social Stress, Social...
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Greenberg, Gian David.
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The Effects of Social Stress, Social Structure, and Agonistic Encounters on Neural Signaling in the Social Decision-Making Network of Rodent Models.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The Effects of Social Stress, Social Structure, and Agonistic Encounters on Neural Signaling in the Social Decision-Making Network of Rodent Models./
作者:
Greenberg, Gian David.
面頁冊數:
133 p.
附註:
Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
Contained By:
Dissertation Abstracts International76-04B(E).
標題:
Neurosciences. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3646298
ISBN:
9781321362664
The Effects of Social Stress, Social Structure, and Agonistic Encounters on Neural Signaling in the Social Decision-Making Network of Rodent Models.
Greenberg, Gian David.
The Effects of Social Stress, Social Structure, and Agonistic Encounters on Neural Signaling in the Social Decision-Making Network of Rodent Models.
- 133 p.
Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
Thesis (Ph.D.)--University of California, Davis, 2014.
This item is not available from ProQuest Dissertations & Theses.
Major depressive disorder and social anxiety are two of the most commonly diagnosed psychiatric disorders in the United States. Many factors contribute to susceptibility to these ailments, such as inherent, varying degrees of vulnerability to environmental triggers (e.g. stressful stimuli) and living situations (e.g. socioeconomic status, family environment, etc.). However, the brain regions and underlying molecular mechanisms responsible for differences in susceptibility to mood disorders are poorly understood. My dissertation examines the effects of social pressures, applied both in a laboratory paradigm and within the home cage, on brain signaling mechanisms associated with social and depressive-like behaviors.
ISBN: 9781321362664Subjects--Topical Terms:
588700
Neurosciences.
The Effects of Social Stress, Social Structure, and Agonistic Encounters on Neural Signaling in the Social Decision-Making Network of Rodent Models.
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Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
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Adviser: Brian C. Trainor.
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Thesis (Ph.D.)--University of California, Davis, 2014.
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This item is not available from ProQuest Dissertations & Theses.
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Major depressive disorder and social anxiety are two of the most commonly diagnosed psychiatric disorders in the United States. Many factors contribute to susceptibility to these ailments, such as inherent, varying degrees of vulnerability to environmental triggers (e.g. stressful stimuli) and living situations (e.g. socioeconomic status, family environment, etc.). However, the brain regions and underlying molecular mechanisms responsible for differences in susceptibility to mood disorders are poorly understood. My dissertation examines the effects of social pressures, applied both in a laboratory paradigm and within the home cage, on brain signaling mechanisms associated with social and depressive-like behaviors.
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There is an evolutionary-conserved network of brain areas that has become a center of attention for studies focusing on behavioral responses to the social challenges that many species encounter throughout their life spans. Within this network, the bed nucleus of the stria teriminalis (BNST) has been identified as a site for integrating signals from the mesolimbic dopamine pathway and the social behavior network, brain circuits that are well-known for underlying many types of social responses and are evolutionary conserved across vertebrate species. In this dissertation, I examined multiple areas of this network, with a primary focus on the BNST, in relation to neural and behavioral responses to social pressures, environments, and stressors. My dissertation includes a comparative approach across three gregarious mammalian species, looking at markers for plasticity-based mechanisms and stress response. In chapter two, I investigated sex-specific effects of social stress in the California mouse. I found stress increased brain-derived neurotrophic factor (BDNF) signaling in the BNST of female but not male mice, and this increase was linked to social withdrawal behavior. In chapter three, I found that early-life social experience produces similar increases in BDNF protein in the BNST of prairie voles. The increases in BDNF in the BNST were associated with increased anxiety-like behavior in voles following early-life parenting experience. In chapter 4, I found that agonistic encounters within the homecage environment of house mice can influence gene expression of two hormone receptors, CRHR2 and ESR1, within the BNST. These receptors are well known as mediators of social behavior and responses to stress. My studies suggest that stress, early-life experience and laboratory environments can have parallel effects on affective behaviors and signaling within the social decision-making network.
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Each animal model employed for experiments in the chapters for my dissertation were important for examining the effects of different types of social encounters. California mice are a monogamous rodent species in which females aggressively defend territories, allowing them to be used as a model for sex differences in social stress. Prairie voles live in extended family groups, and they are a great model for complex social relationships, including early parenting experience. Agonistic interactions are common in C57Bl/6 mice, and they are a frequently used animal model for neurobiological studies. My studies on social influences on behavior, from social dynamics within the home cage to laboratory-induced social stressors, suggest that the BNST and other nodes within a social behavior network undergo changes in gene and protein expression following complex social interactions.
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3646298
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