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[ subject:"Neurosciences." ]
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Synaptic Physiology and Modulation i...
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Seong, Hannah.
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Synaptic Physiology and Modulation in the Prefrontal Cortex.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Synaptic Physiology and Modulation in the Prefrontal Cortex./
作者:
Seong, Hannah.
面頁冊數:
152 p.
附註:
Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
Contained By:
Dissertation Abstracts International77-07B(E).
標題:
Neurosciences. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10025710
ISBN:
9781339521503
Synaptic Physiology and Modulation in the Prefrontal Cortex.
Seong, Hannah.
Synaptic Physiology and Modulation in the Prefrontal Cortex.
- 152 p.
Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
Thesis (Ph.D.)--New York University, 2016.
Diverse receptors and ion channels are present in the neuronal membrane and are fundamental to the functioning of individual synapses and cells. At the level of spines they orchestrate complex synaptic responses to shape the local electrical and chemical environment. At the cellular level they govern excitability and firing of different populations of neurons in the brain. Thus the interplay of receptors and ion channels, their recruitment, and modulation are critical areas of studies for understanding both sub- and supra-threshold activities in neurons. In the prefrontal cortex these have widespread implications for cognitive functions and neuropsychiatric diseases.
ISBN: 9781339521503Subjects--Topical Terms:
588700
Neurosciences.
Synaptic Physiology and Modulation in the Prefrontal Cortex.
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Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
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Adviser: Adam G. Carter.
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Thesis (Ph.D.)--New York University, 2016.
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Diverse receptors and ion channels are present in the neuronal membrane and are fundamental to the functioning of individual synapses and cells. At the level of spines they orchestrate complex synaptic responses to shape the local electrical and chemical environment. At the cellular level they govern excitability and firing of different populations of neurons in the brain. Thus the interplay of receptors and ion channels, their recruitment, and modulation are critical areas of studies for understanding both sub- and supra-threshold activities in neurons. In the prefrontal cortex these have widespread implications for cognitive functions and neuropsychiatric diseases.
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This thesis focuses at layer 5 pyramidal neurons in the prefrontal cortex on subcellular synaptic signaling, cellular physiology, and neuromodulation. My research explored the impact of subthreshold membrane potential on synaptic responses at dendritic spines of layer 5 pyramidal neurons in the prefrontal cortex, and D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex. I utilized a wide range of approaches including BAC transgenics, whole-cell recordings, pharmacology, two-photon microscopy and two-photon glutamate uncaging. The first chapter of my work describes how synaptic potentials and Ca2+ signaling at individual spines depends on the sub-threshold resting membrane potential of the cell. It also examines the dynamic interplay between multiple glutamate receptors and ion channels to coordinate these local signaling. The second chapter describes physiological and morphological diversity within layer 5 pyramidal neurons, and a distinct subpopulation of D1 receptor-expressing neurons that undergo robust modulation via the PKA pathway to enhance firing. Together, they highlight novel roles for receptors and ion channels in the prefrontal cortex, with broad implications for synapse, neuron, and circuit function, as well as cognitive functions and diseases.
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10025710
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