語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
到查詢結果
[ subject:"Biomedical engineering." ]
切換:
標籤
|
MARC模式
|
ISBD
The role of the nucleus pulposus in ...
~
Showalter, Brent L.
FindBook
Google Book
Amazon
博客來
The role of the nucleus pulposus in human intervertebral disc mechanical function quantified by mechanical loading and non-invasive imaging.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The role of the nucleus pulposus in human intervertebral disc mechanical function quantified by mechanical loading and non-invasive imaging./
作者:
Showalter, Brent L.
面頁冊數:
122 p.
附註:
Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Contained By:
Dissertation Abstracts International76-11B(E).
標題:
Biomedical engineering. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3709554
ISBN:
9781321851854
The role of the nucleus pulposus in human intervertebral disc mechanical function quantified by mechanical loading and non-invasive imaging.
Showalter, Brent L.
The role of the nucleus pulposus in human intervertebral disc mechanical function quantified by mechanical loading and non-invasive imaging.
- 122 p.
Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Thesis (Ph.D.)--University of Pennsylvania, 2015.
The intervertebral disc performs the mechanical roles of supporting loads, permitting motion, and dissipating energy. Disc degeneration affects a large portion of the population, reduces the joint's effectiveness, and is strongly implicated as a cause of low back pain. Degeneration is an irreversible process that manifests early within the centralized nucleus pulposus and subsequently affects other disc components. An incomplete understanding of the role of the nucleus pulposus and how alterations in nucleus function affect disc mechanics has hindered successful development of disc degeneration treatment. The objective of this dissertation was to evaluate the mechanical contributions of the nucleus pulposus to intervertebral disc function in compressive loading. In cyclic loading experiments, it was determined that removal of the nucleus pulposus via nucleotomy caused acute changes to the disc's mechanical response such as a decrease in compressive stiffness with an accompanying increase in compressive strain. These changes correspond to hypermobility, which alters overall spinal mechanics and may impact low back pain via altered motion throughout the spinal column. In addition to these acute changes, nucleotomy also decreased the fluid-flow related effects of cyclic compressive loading. Filing the void left by nucleotomy with a hydrogel implant preserved the creep response of the discs. A procedure for creating disc strain templates, which describe average disc strain, from MR images taken before and after loading was developed to non-invasively measure internal disc strains that result from compression loading. In mildly-degenerate human discs, removal of the nucleus increased axial strain throughout the annulus fibrosus, consistent with the existing literature stating that the nucleus plays a significant role in supporting compressive loads. Removal of the nucleus also unevenly altered the distribution of circumferential and radial strains within the annulus. Nucleotomy caused substantially higher circumferential strain in the posterolateral region, which may increase the risk of annular tears. The novel tools developed in this work and the experimental results can be utilized to further understand the mechanical role of the nucleus pulposus on intervertebral disc function, how that role changes with degeneration, and to design and treatments that restore disc mechanics.
ISBN: 9781321851854Subjects--Topical Terms:
535387
Biomedical engineering.
The role of the nucleus pulposus in human intervertebral disc mechanical function quantified by mechanical loading and non-invasive imaging.
LDR
:03335nmm a2200265 4500
001
2064304
005
20151109142632.5
008
170521s2015 ||||||||||||||||| ||eng d
020
$a
9781321851854
035
$a
(MiAaPQ)AAI3709554
035
$a
AAI3709554
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Showalter, Brent L.
$3
3178872
245
1 4
$a
The role of the nucleus pulposus in human intervertebral disc mechanical function quantified by mechanical loading and non-invasive imaging.
300
$a
122 p.
500
$a
Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
500
$a
Adviser: Dawn M. Elliott.
502
$a
Thesis (Ph.D.)--University of Pennsylvania, 2015.
520
$a
The intervertebral disc performs the mechanical roles of supporting loads, permitting motion, and dissipating energy. Disc degeneration affects a large portion of the population, reduces the joint's effectiveness, and is strongly implicated as a cause of low back pain. Degeneration is an irreversible process that manifests early within the centralized nucleus pulposus and subsequently affects other disc components. An incomplete understanding of the role of the nucleus pulposus and how alterations in nucleus function affect disc mechanics has hindered successful development of disc degeneration treatment. The objective of this dissertation was to evaluate the mechanical contributions of the nucleus pulposus to intervertebral disc function in compressive loading. In cyclic loading experiments, it was determined that removal of the nucleus pulposus via nucleotomy caused acute changes to the disc's mechanical response such as a decrease in compressive stiffness with an accompanying increase in compressive strain. These changes correspond to hypermobility, which alters overall spinal mechanics and may impact low back pain via altered motion throughout the spinal column. In addition to these acute changes, nucleotomy also decreased the fluid-flow related effects of cyclic compressive loading. Filing the void left by nucleotomy with a hydrogel implant preserved the creep response of the discs. A procedure for creating disc strain templates, which describe average disc strain, from MR images taken before and after loading was developed to non-invasively measure internal disc strains that result from compression loading. In mildly-degenerate human discs, removal of the nucleus increased axial strain throughout the annulus fibrosus, consistent with the existing literature stating that the nucleus plays a significant role in supporting compressive loads. Removal of the nucleus also unevenly altered the distribution of circumferential and radial strains within the annulus. Nucleotomy caused substantially higher circumferential strain in the posterolateral region, which may increase the risk of annular tears. The novel tools developed in this work and the experimental results can be utilized to further understand the mechanical role of the nucleus pulposus on intervertebral disc function, how that role changes with degeneration, and to design and treatments that restore disc mechanics.
590
$a
School code: 0175.
650
4
$a
Biomedical engineering.
$3
535387
690
$a
0541
710
2
$a
University of Pennsylvania.
$b
Bioengineering.
$3
3178873
773
0
$t
Dissertation Abstracts International
$g
76-11B(E).
790
$a
0175
791
$a
Ph.D.
792
$a
2015
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3709554
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9296962
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入