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[ subject:"Biomedical engineering." ]
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Biomechanical Testing Of An Adhesive...
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Kerr, Mayuri Mohan Panse.
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Biomechanical Testing Of An Adhesive Polymer Intended For The Treatment Of Retinal Detachment.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Biomechanical Testing Of An Adhesive Polymer Intended For The Treatment Of Retinal Detachment./
作者:
Kerr, Mayuri Mohan Panse.
面頁冊數:
69 p.
附註:
Source: Masters Abstracts International, Volume: 53-01.
Contained By:
Masters Abstracts International53-01(E).
標題:
Biomedical engineering. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1557810
ISBN:
9781303959660
Biomechanical Testing Of An Adhesive Polymer Intended For The Treatment Of Retinal Detachment.
Kerr, Mayuri Mohan Panse.
Biomechanical Testing Of An Adhesive Polymer Intended For The Treatment Of Retinal Detachment.
- 69 p.
Source: Masters Abstracts International, Volume: 53-01.
Thesis (M.S.)--University of California, Los Angeles, 2014.
This item must not be sold to any third party vendors.
Untreated retinal detachment can lead to blindness. Contemporary treatments involve the use of scleral buckles, or tamponade agents, to appose the retina against the choroid anchor, followed by "welding" the retina to the choroid with laser or cryopexy. While effective at reattachment, these procedures result in the formation of scar tissue that is devoid of function and subjects the surrounding tissue to mechanical strains leading to potential re-detachment. In addition, the scarring of tissue can require several weeks to completely adhere to the underlying ocular tissues, resulting in additional discomfort for the patient. A novel Polyethylene glycol (PEG)-based adhesive polymer, recently developed by Medicus Biosciences, aims to re-attach the retina while avoiding the complications of current treatments. This optically clear, biocompatible adhesive can be applied quickly and will hold the retina in place while retaining function and avoiding the formation of scar tissue. However, to avoid artificial mechanical strains upon the surrounding tissue, the mechanical properties of the polymer must be similar to those of the healthy retina to allow proper healing and regeneration. The present study is a comparative evaluation of the mechanical properties of the Medicus Polymer to that of healthy intact retinal tissue supported by surrounding tissues. Intact harvested porcine eyes were used for static and dynamic testing of the intact retina, torn retina, and polymer-sealed retina. Our static tests reveal that the Medicus polymer is mechanically stiffer than the intact retina with a Young's modulus of 2160 +/- 923 kPa relative to that of the intact retina supported by surrounding tissues at 278 +/- 158 kPa. The dynamic testing resulted in a contradictory result with the intact retinal stiffness determined to be 116 +/- 72.7 kPa compared to 54.5 +/- 25.2 kPa of the polymer sealed retina. The polymer does, however, match the resilience of the retina with the intact retina resulting in 60.79 +/- 4.68% compared to the 58.11 +/- 12.90% resilience of the polymer-sealed retina. Finally, the yield and failure strengths of the polymer and intact retina were not significantly different.
ISBN: 9781303959660Subjects--Topical Terms:
535387
Biomedical engineering.
Biomechanical Testing Of An Adhesive Polymer Intended For The Treatment Of Retinal Detachment.
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Untreated retinal detachment can lead to blindness. Contemporary treatments involve the use of scleral buckles, or tamponade agents, to appose the retina against the choroid anchor, followed by "welding" the retina to the choroid with laser or cryopexy. While effective at reattachment, these procedures result in the formation of scar tissue that is devoid of function and subjects the surrounding tissue to mechanical strains leading to potential re-detachment. In addition, the scarring of tissue can require several weeks to completely adhere to the underlying ocular tissues, resulting in additional discomfort for the patient. A novel Polyethylene glycol (PEG)-based adhesive polymer, recently developed by Medicus Biosciences, aims to re-attach the retina while avoiding the complications of current treatments. This optically clear, biocompatible adhesive can be applied quickly and will hold the retina in place while retaining function and avoiding the formation of scar tissue. However, to avoid artificial mechanical strains upon the surrounding tissue, the mechanical properties of the polymer must be similar to those of the healthy retina to allow proper healing and regeneration. The present study is a comparative evaluation of the mechanical properties of the Medicus Polymer to that of healthy intact retinal tissue supported by surrounding tissues. Intact harvested porcine eyes were used for static and dynamic testing of the intact retina, torn retina, and polymer-sealed retina. Our static tests reveal that the Medicus polymer is mechanically stiffer than the intact retina with a Young's modulus of 2160 +/- 923 kPa relative to that of the intact retina supported by surrounding tissues at 278 +/- 158 kPa. The dynamic testing resulted in a contradictory result with the intact retinal stiffness determined to be 116 +/- 72.7 kPa compared to 54.5 +/- 25.2 kPa of the polymer sealed retina. The polymer does, however, match the resilience of the retina with the intact retina resulting in 60.79 +/- 4.68% compared to the 58.11 +/- 12.90% resilience of the polymer-sealed retina. Finally, the yield and failure strengths of the polymer and intact retina were not significantly different.
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