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Dna-encoded libraries

Brunschweiger, Andreas.

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Dna-encoded libraries

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dna-encoded libraries/ edited by Andreas Brunschweiger, Damian W. Young ; with contributions by M. J. Anderson ... [et al.].
other author:	Brunschweiger, Andreas.
Published:	Cham :Springer International Publishing : : 2022.,
Description:	ix, 276 p. :ill., digital ;24 cm.
[NT 15003449]:	A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry.
Contained By:	Springer Nature eBook
Subject:	Combinatorial chemistry. -
Online resource:	https://doi.org/10.1007/978-3-031-18629-5
ISBN:	9783031186295

Dna-encoded libraries
Dna-encoded libraries[electronic resource] /edited by Andreas Brunschweiger, Damian W. Young ; with contributions by M. J. Anderson ... [et al.]. - Cham :Springer International Publishing :2022. - ix, 276 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,v. 401862-247X ;. - Topics in medicinal chemistry ;v. 40..

A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry.

This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.

ISBN: 9783031186295

Standard No.: 10.1007/978-3-031-18629-5doiSubjects--Topical Terms:

605680
Combinatorial chemistry.

LC Class. No.: RS419

Dewey Class. No.: 615.19

Dna-encoded libraries
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260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2022.
300 $a ix, 276 p. : $b ill., digital ; $c 24 cm.
490 1 $a Topics in medicinal chemistry, $x 1862-247X ; $v v. 40
505 0 $a A History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry.
520 $a This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.
650 0 $a Combinatorial chemistry. $3 605680
650 0 $a DNA $x Synthesis. $3 683694
700 1 $a Brunschweiger, Andreas. $3 3608512
700 1 $a Young, Damian W. $3 3608513
700 1 $a Anderson, M. J., $e contributor. $3 3608514
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830 0 $a Topics in medicinal chemistry ; $v v. 40. $3 3608515
856 4 0 $u https://doi.org/10.1007/978-3-031-18629-5
950 $a Chemistry and Materials Science (SpringerNature-11644)